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Obesity

Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance.

Jersin R Å, Tallapragada DSP, Madsen A, et al. Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance. Diabetes. 2021;70(3):680-695. doi:10.2337/db20-0096

Mesothelial cells are not a source of adipocytes in mice.

Westcott GP, Emont MP, Li J, Jacobs C, Tsai L, Rosen ED. Mesothelial cells are not a source of adipocytes in mice. Cell reports. 2021;36(2):109388. doi:10.1016/j.celrep.2021.109388

A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function.

Honecker J, Weidlich D, Heisz S, et al. A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function. International journal of obesity (2005). 2021;45(9):2108-2117. doi:10.1038/s41366-021-00883-6

Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.

Li J, Li E, Czepielewski RS, et al. Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells. Cell metabolism. 2021;33(7):1449-1465.e6. doi:10.1016/j.cmet.2021.04.019

IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis.

Yan S, Kumari M, Xiao H, et al. IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis. The Journal of clinical investigation. 2021;131(7). doi:10.1172/JCI144888

Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations.

Cole JB, Florez JC, Hirschhorn JN. Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations. Nat Commun. 2020;11(1):1467. doi:10.1038/s41467-020-15193-0

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome.

Hsu YHH, Astley CM, Cole JB, et al. Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome. International journal of obesity (2005). 2020;44(7):1596-1606. doi:10.1038/s41366-020-0603-x

A MicroRNA Linking Human Positive Selection and Metabolic Disorders.

Wang L, Sinnott-Armstrong N, Wagschal A, et al. A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. 2020;183(3):684-701.e14. doi:10.1016/j.cell.2020.09.017

Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling.

Roh HC, Kumari M, Taleb S, et al. Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling. Molecular metabolism. 2020;42:101086. doi:10.1016/j.molmet.2020.101086

Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits.

Glastonbury CA, Pulit SL, Honecker J, et al. Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits. PLoS computational biology. 2020;16(8):e1008044. doi:10.1371/journal.pcbi.1008044