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Publications

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery.

Rees HA, Komor AC, Yeh WH, et al. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery. Nat Commun. 2017;8:15790. doi:10.1038/ncomms15790

Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis.

Sung J, Kim S, Cabatbat JJT, et al. Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis. Nat Commun. 2017;8:15393. doi:10.1038/ncomms15393

Palaeogenomes of Eurasian straight-tusked elephants challenge the current view of elephant evolution.

Meyer M, Palkopoulou E, Baleka S, et al. Palaeogenomes of Eurasian straight-tusked elephants challenge the current view of elephant evolution. Elife. 2017;6. doi:10.7554/eLife.25413

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

Christophersen IE, Rienstra M, Roselli C, et al. Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet. 2017;49(6):946-952. doi:10.1038/ng.3843

Mycobacterium tuberculosis Whole Genome Sequences From Southern India Suggest Novel Resistance Mechanisms and the Need for Region-Specific Diagnostics.

Manson AL, Abeel T, Galagan JE, et al. Mycobacterium tuberculosis Whole Genome Sequences From Southern India Suggest Novel Resistance Mechanisms and the Need for Region-Specific Diagnostics. Clin Infect Dis. 2017;64(11):1494-1501. doi:10.1093/cid/cix169

Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms.

Lubitz SA, Parsons OE, Anderson CD, et al. Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms. Stroke. 2017;48(6):1451-1456. doi:10.1161/STROKEAHA.116.016198

Transcriptional regulatory dynamics drive coordinated metabolic and neural response to social challenge in mice.

Saul MC, Seward CH, Troy JM, et al. Transcriptional regulatory dynamics drive coordinated metabolic and neural response to social challenge in mice. Genome Res. 2017;27(6):959-972. doi:10.1101/gr.214221.116

RPC4046, A Novel Anti-interleukin-13 Antibody, Blocks IL-13 Binding to IL-13 α1 and α2 Receptors: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation First-in-Human Study.

Tripp CS, Cuff C, Campbell AL, et al. RPC4046, A Novel Anti-interleukin-13 Antibody, Blocks IL-13 Binding to IL-13 α1 and α2 Receptors: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation First-in-Human Study. Adv Ther. 2017;34(6):1364-1381. doi:10.1007/s12325-017-0525-8

The immunoproteasome is induced by cytokines and regulates apoptosis in human islets.

Lundh M, Bugliani M, Dahlby T, et al. The immunoproteasome is induced by cytokines and regulates apoptosis in human islets. J Endocrinol. 2017;233(3):369-379. doi:10.1530/JOE-17-0110

Genome-wide profiling of heritable and de novo STR variations.

Willems T, Zielinski D, Yuan J, Gordon A, Gymrek M, Erlich Y iv. Genome-wide profiling of heritable and de novo STR variations. Nat Methods. 2017;14(6):590-592. doi:10.1038/nmeth.4267