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Publications

A visual-language foundation model for computational pathology.

Lu MY, Chen B, Williamson DFK, et al. A visual-language foundation model for computational pathology. Nature medicine. 2024. doi:10.1038/s41591-024-02856-4

Towards a general-purpose foundation model for computational pathology.

Chen RJ, Ding T, Lu MY, et al. Towards a general-purpose foundation model for computational pathology. Nature medicine. 2024. doi:10.1038/s41591-024-02857-3

Multicenter integrated analysis of noncoding CRISPRi screens.

Yao D, Tycko J, Oh JW, et al. Multicenter integrated analysis of noncoding CRISPRi screens. Nature methods. 2024. doi:10.1038/s41592-024-02216-7

An Anatomical and Physiological Basis for Coincidence Detection Across Time Scales in the Auditory System.

Kreeger LJ, Honnuraiah S, Maeker S, Shea S, Fishell G, Goodrich L V. An Anatomical and Physiological Basis for Coincidence Detection Across Time Scales in the Auditory System. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.02.29.582808

APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.

Jackson RJ, Keiser MS, Meltzer JC, et al. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. Molecular therapy : the journal of the American Society of Gene Therapy. 2024. doi:10.1016/j.ymthe.2024.03.024

Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study.

Kerola AM, Palomäki A, Laivuori H, et al. Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study. Rheumatology (Oxford, England). 2024. doi:10.1093/rheumatology/keae122

Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.

Ganz J, Luquette LJ, Bizzotto S, et al. Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes. Cell. 2024. doi:10.1016/j.cell.2024.02.025

Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes.

Sanchez A, Ortega P, Sakhtemani R, et al. Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. Nature communications. 2024;15(1):2370. doi:10.1038/s41467-024-45909-5

Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.

Butt Y, Sakhtemani R, Mohamad-Ramshan R, Lawrence MS, Bhagwat AS. Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations. Nature communications. 2024;15(1):2369. doi:10.1038/s41467-024-46231-w

Lac-Phe mediates the effects of metformin on food intake and body weight.

Xiao S, Li VL, Lyu X, et al. Lac-Phe mediates the effects of metformin on food intake and body weight. Nature metabolism. 2024. doi:10.1038/s42255-024-00999-9