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Publications

Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation.

Neale I, Reddy C, Tan ZY, et al. Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation. Science advances. 2024;10(29):eadn2339. doi:10.1126/sciadv.adn2339

Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study.

Rajasundaram S, Segrè A V, Gill D, et al. Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study. Investigative ophthalmology & visual science. 2024;65(8):35. doi:10.1167/iovs.65.8.35

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer.

Duplaquet L, So K, Ying AW, et al. Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer. Cancer cell. 2024. doi:10.1016/j.ccell.2024.06.012

Unsupervised representation learning of chromatin images identifies changes in cell state and tissue organization in DCIS.

Zhang X, Venkatachalapathy S, Paysan D, et al. Unsupervised representation learning of chromatin images identifies changes in cell state and tissue organization in DCIS. Nature communications. 2024;15(1):6112. doi:10.1038/s41467-024-50285-1

CRISPRi-TnSeq maps genome-wide interactions between essential and non-essential genes in bacteria.

Jana B, Liu X, Dénéréaz J, et al. CRISPRi-TnSeq maps genome-wide interactions between essential and non-essential genes in bacteria. Nature microbiology. 2024. doi:10.1038/s41564-024-01759-x

Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist.

Lim SS, Semnani-Azad Z, Morieri ML, et al. Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist. Nature medicine. 2024;30(7):1874-1881. doi:10.1038/s41591-024-03033-3

A benchmark of computational methods for correcting biases of established and unknown origin in CRISPR-Cas9 screening data.

Vinceti A, Iannuzzi RM, Boyle I, et al. A benchmark of computational methods for correcting biases of established and unknown origin in CRISPR-Cas9 screening data. Genome biology. 2024;25(1):192. doi:10.1186/s13059-024-03336-1

Assessment of the evidence yield for the calibrated PP3/BP4 computational recommendations.

Stenton SL, Pejaver V, Bergquist T, et al. Assessment of the evidence yield for the calibrated PP3/BP4 computational recommendations. Genetics in medicine : official journal of the American College of Medical Genetics. 2024:101213. doi:10.1016/j.gim.2024.101213

Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus.

Rasetto NB, Giacomini D, Berardino AA, et al. Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus. Science advances. 2024;10(29):eadp6039. doi:10.1126/sciadv.adp6039

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.

Strom NI, Verhulst B, Bacanu SA, et al. Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling. medRxiv : the preprint server for health sciences. 2024. doi:10.1101/2024.07.03.24309466