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Publications

Complex genetic variation in nearly complete human genomes.

Logsdon GA, Ebert P, Audano PA, et al. Complex genetic variation in nearly complete human genomes. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.09.24.614721

Discovery of electrophilic degraders that exploit SAr chemistry.

Zhuang Z, Byun WS, Kozicka Z, et al. Discovery of electrophilic degraders that exploit SAr chemistry. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.09.25.615094

Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein.

Zhao Z, Zhou J, Shi A, et al. Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein. Journal of hazardous materials. 2024;480:136090. doi:10.1016/j.jhazmat.2024.136090

Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors.

Burr R, Leshchiner I, Costantino CL, et al. Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors. Nature cancer. 2024. doi:10.1038/s43018-024-00840-y

Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein.

Zhao Z, Zhou J, Shi A, et al. Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein. Journal of hazardous materials. 2024;480:136090. doi:10.1016/j.jhazmat.2024.136090

UROPOT: study protocol for a randomized, double-blind phase I/II trial for metabolism-based potentiation of antimicrobial prophylaxis in the urological tract.

Stritt K, Roth B, Masnada A, et al. UROPOT: study protocol for a randomized, double-blind phase I/II trial for metabolism-based potentiation of antimicrobial prophylaxis in the urological tract. Trials. 2024;25(1):682. doi:10.1186/s13063-024-08526-7

Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors.

Burr R, Leshchiner I, Costantino CL, et al. Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors. Nature cancer. 2024. doi:10.1038/s43018-024-00840-y

Discovery of BAY 2666605, a Molecular Glue for PDE3A and SLFN12.

Lewis TA, Ellermann M, Kopitz C, et al. Discovery of BAY 2666605, a Molecular Glue for PDE3A and SLFN12. ACS medicinal chemistry letters. 2024;15(10):1662-1667. doi:10.1021/acsmedchemlett.4c00336

UROPOT: study protocol for a randomized, double-blind phase I/II trial for metabolism-based potentiation of antimicrobial prophylaxis in the urological tract.

Stritt K, Roth B, Masnada A, et al. UROPOT: study protocol for a randomized, double-blind phase I/II trial for metabolism-based potentiation of antimicrobial prophylaxis in the urological tract. Trials. 2024;25(1):682. doi:10.1186/s13063-024-08526-7

"Monitoring inflammatory, immune system mediators, and mitochondrial changes related to brain metabolism during space flight".

Tocci D, Ducai T, Stoute CAB, et al. "Monitoring inflammatory, immune system mediators, and mitochondrial changes related to brain metabolism during space flight". Frontiers in immunology. 2024;15:1422864. doi:10.3389/fimmu.2024.1422864