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Publications

Pathway-Specific Polygenic Scores Improve Cross-Ancestry Prediction of Psychosis and Clinical Outcomes.

Tubbs JD, Leung PBM, Zhong Y, et al. Pathway-Specific Polygenic Scores Improve Cross-Ancestry Prediction of Psychosis and Clinical Outcomes. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.09.01.23294957

Synthetic control of actin polymerization and symmetry breaking in active protocells.

Razavi S, Wong F, Abubaker-Sharif B, et al. Synthetic control of actin polymerization and symmetry breaking in active protocells. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.09.22.559060

Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor.

Blum SM, Zlotoff DA, Smith NP, et al. Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.09.15.557794

TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses.

Ding Q, Wu Y, Triglia ET, et al. TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.09.22.558524

Distinct explanations underlie gene-environment interactions in the UK Biobank.

Durvasula A, Price AL. Distinct explanations underlie gene-environment interactions in the UK Biobank. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.09.22.23295969

Germline mutations and developmental mosaicism underlying -mutant lung cancer.

Burr R, Leshchiner I, Costantino CL, et al. Germline mutations and developmental mosaicism underlying -mutant lung cancer. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.09.28.23296274

Functional genomics implicates natural killer cells as potential key drivers in the pathogenesis of ankylosing spondylitis.

Chiñas M, Fernandez-Salinas D, Aguiar VRC, et al. Functional genomics implicates natural killer cells as potential key drivers in the pathogenesis of ankylosing spondylitis. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.09.21.23295912

Rare variant association analysis in 51,256 type 2 diabetes cases and 370,487 controls informs the spectrum of pathogenicity of monogenic diabetes genes.

Schroeder P, Mandla R, Huerta-Chagoya A, et al. Rare variant association analysis in 51,256 type 2 diabetes cases and 370,487 controls informs the spectrum of pathogenicity of monogenic diabetes genes. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.09.28.23296244

Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB.

Munir M, Embry A, Doench JG, Heaton NS, Wilen CB, Orchard RC. Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.09.29.560128

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity.

Smith K, Deutsch AJ, McGrail C, et al. Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.09.28.23296294