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Publications

DNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming.

Gritti I, Wan J, Weeresekara V, et al. DNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming. Cancer discovery. 2024. doi:10.1158/2159-8290.CD-24-0634

Identifying genetic variants that influence the abundance of cell states in single-cell data.

Rumker L, Sakaue S, Reshef Y, et al. Identifying genetic variants that influence the abundance of cell states in single-cell data. Nature genetics. 2024. doi:10.1038/s41588-024-01909-1

Droplet-based functional CRISPR screening of cell-cell interactions by SPEAC-seq.

Akl CF, Linnerbauer M, Li Z, et al. Droplet-based functional CRISPR screening of cell-cell interactions by SPEAC-seq. Nature protocols. 2024. doi:10.1038/s41596-024-01056-1

Exercise Intolerance and Low Cardiac Filling Pressures in a Woman With a Novel eNOS Mutation.

McGarrity S, Ziehr DR, Austin-Tse CA, Wein MN, Chivukula RR, Oldham WM. Exercise Intolerance and Low Cardiac Filling Pressures in a Woman With a Novel eNOS Mutation. Circulation. Genomic and precision medicine. 2024:e004741. doi:10.1161/CIRCGEN.124.004741

Associations of "Weekend Warrior" Physical Activity With Incident Disease and Cardiometabolic Health.

Kany S, Al-Alusi MA, Rämö JT, et al. Associations of "Weekend Warrior" Physical Activity With Incident Disease and Cardiometabolic Health. Circulation. 2024. doi:10.1161/CIRCULATIONAHA.124.068669

Scalable summary-statistics-based heritability estimation method with individual genotype level accuracy.

Jeong M, Pazokitoroudi A, Liu Z, Sankararaman S. Scalable summary-statistics-based heritability estimation method with individual genotype level accuracy. Genome research. 2024. doi:10.1101/gr.279207.124

Characterization of additive gene-environment interactions for colorectal cancer risk.

Thomas CE, Lin Y, Kim M, et al. Characterization of additive gene-environment interactions for colorectal cancer risk. Epidemiology (Cambridge, Mass.). 2024. doi:10.1097/EDE.0000000000001795

Social complexity of a fentanyl vaccine to prevent opioid overdose conference proceedings: Radcliffe institute for advanced study conference proceedings.

Weitzman ER, . Social complexity of a fentanyl vaccine to prevent opioid overdose conference proceedings: Radcliffe institute for advanced study conference proceedings. Vaccine. 2024:126324. doi:10.1016/j.vaccine.2024.126324

Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance.

Wang QS, Hasegawa T, Namkoong H, et al. Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance. Nature genetics. 2024. doi:10.1038/s41588-024-01896-3

Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution.

Schiffman JS, D’Avino AR, Prieto T, et al. Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution. Nature genetics. 2024. doi:10.1038/s41588-024-01920-6