Publications

Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk.

Jiang X, Zhang MJ, Zhang Y, et al. Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk. Nature genetics. 2023. doi:10.1038/s41588-023-01522-8

Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease.

Wilton DK, Mastro K, Heller MD, et al. Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease. Nature medicine. 2023. doi:10.1038/s41591-023-02566-3

Cases of familial idiopathic normal pressure hydrocephalus implicate genetic factors in disease pathogenesis.

Greenberg ABW, Mehta NH, Mekbib KY, et al. Cases of familial idiopathic normal pressure hydrocephalus implicate genetic factors in disease pathogenesis. Cerebral cortex (New York, N.Y. : 1991). 2023. doi:10.1093/cercor/bhad374

A two-cohort study on the association between the gut microbiota and bone density, microarchitecture, and strength.

Okoro PC, Orwoll ES, Huttenhower C, et al. A two-cohort study on the association between the gut microbiota and bone density, microarchitecture, and strength. Frontiers in endocrinology. 2023;14:1237727. doi:10.3389/fendo.2023.1237727

An improved rhythmicity analysis method using Gaussian Processes detects cell-density dependent circadian oscillations in stem cells.

Sahay S, Adhikari S, Hormoz S, Chakrabarti S. An improved rhythmicity analysis method using Gaussian Processes detects cell-density dependent circadian oscillations in stem cells. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.21.533651

High-content microscopy reveals a morphological signature of bortezomib resistance.

Kelley ME, Berman AY, Stirling DR, et al. High-content microscopy reveals a morphological signature of bortezomib resistance. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.05.02.539137

Early Alzheimer's disease pathology in human cortex is associated with a transient phase of distinct cell states.

Gazestani V, Kamath T, Nadaf NM, et al. Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell states. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.06.03.543569

EZH2 synergizes with BRD4-NUT to drive NUT carcinoma growth through silencing of key tumor suppressor genes.

Huang Y, Durall T, Luong NM, et al. EZH2 synergizes with BRD4-NUT to drive NUT carcinoma growth through silencing of key tumor suppressor genes. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.08.15.553204

Precision medicine of obesity as an integral part of type 2 diabetes management - past, present, and future.

Szczerbiński L, Florez JC. Precision medicine of obesity as an integral part of type 2 diabetes management - past, present, and future. The lancet. Diabetes & endocrinology. 2023. doi:10.1016/S2213-8587(23)00232-2

Precision medicine for cardiometabolic disease: a framework for clinical translation.

Franks PW, Cefalu WT, Dennis J, et al. Precision medicine for cardiometabolic disease: a framework for clinical translation. The lancet. Diabetes & endocrinology. 2023. doi:10.1016/S2213-8587(23)00165-1