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Publications

Volatile anesthetic isoflurane exposure facilitates Enterococcus biofilm infection.

Maisat W, Yuki K. Volatile anesthetic isoflurane exposure facilitates Enterococcus biofilm infection. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023;37(10):e23186. doi:10.1096/fj.202301128R

Nuclear genetic control of mtDNA copy number and heteroplasmy in humans.

Gupta R, Kanai M, Durham TJ, et al. Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.01.19.23284696

Advanced variant classification framework reduces the false positive rate of predicted loss of function (pLoF) variants in population sequencing data.

Singer-Berk M, Gudmundsson S, Baxter S, et al. Advanced variant classification framework reduces the false positive rate of predicted loss of function (pLoF) variants in population sequencing data. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.03.08.23286955

RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.

Martell DJ, Merens HE, Fiorini C, et al. RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.03.03.23286760

Omics-driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability.

Hota M, Barber JL, Ruiz-Ramie JJ, et al. Omics-driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability. Physiological genomics. 2023. doi:10.1152/physiolgenomics.00163.2022

The N-end rule pathway regulates ER stress-induced clusterin release to the cytosol where it directs misfolded proteins for degradation.

Satapathy S, Walker H, Brown J, Gambin Y, Wilson MR. The N-end rule pathway regulates ER stress-induced clusterin release to the cytosol where it directs misfolded proteins for degradation. Cell reports. 2023;42(9):113059. doi:10.1016/j.celrep.2023.113059

Phage-assisted evolution and protein engineering yield compact, efficient prime editors.

Doman JL, Pandey S, Neugebauer ME, et al. Phage-assisted evolution and protein engineering yield compact, efficient prime editors. Cell. 2023;186(18):3983-4002.e26. doi:10.1016/j.cell.2023.07.039

BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep.

Rojo D, Dal Cengio L, Badner A, et al. BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep. Neuron. 2023. doi:10.1016/j.neuron.2023.08.002

Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice.

Farsi Z, Nicolella A, Simmons SK, et al. Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice. Neuron. 2023. doi:10.1016/j.neuron.2023.08.004

Empirical evaluation of language modeling to ascertain cancer outcomes from clinical text reports.

Elmarakeby HA, Trukhanov PS, Arroyo VM, et al. Empirical evaluation of language modeling to ascertain cancer outcomes from clinical text reports. BMC bioinformatics. 2023;24(1):328. doi:10.1186/s12859-023-05439-1