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Publications

An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery.

Huang Q, Chan KY, Lou S, et al. An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.12.20.572615

Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas.

Hughes O, Bentley AR, Breeze CE, et al. Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas. Cell genomics. 2023;4(1):100468. doi:10.1016/j.xgen.2023.100468

Predicting patient outcomes after treatment with immune checkpoint blockade: A review of biomarkers derived from diverse data modalities.

Liu Y, Altreuter J, Bodapati S, et al. Predicting patient outcomes after treatment with immune checkpoint blockade: A review of biomarkers derived from diverse data modalities. Cell genomics. 2023;4(1):100444. doi:10.1016/j.xgen.2023.100444

Whole-genome long-read sequencing downsampling and its effect on variant-calling precision and recall.

Harvey WT, Ebert P, Ebler J, et al. Whole-genome long-read sequencing downsampling and its effect on variant-calling precision and recall. Genome research. 2023;33(12):2029-2040. doi:10.1101/gr.278070.123

Biomarker changes preceding symptom onset in genetic prion disease.

Vallabh SM, Mortberg MA, Allen SW, et al. Biomarker changes preceding symptom onset in genetic prion disease. medRxiv : the preprint server for health sciences. 2023. doi:10.1101/2023.12.18.23300042

Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease.

Lin J, Mars N, Fu Y, et al. Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease. JACC. Basic to translational science. 2023;8(12):1489-1499. doi:10.1016/j.jacbts.2023.07.006

Improving Polygenic Risk Scores for Coronary Artery Disease: What Helps and by How Much?

Ajufo EC, Aragam KG. Improving Polygenic Risk Scores for Coronary Artery Disease: What Helps and by How Much? JACC. Basic to translational science. 2023;8(12):1500-1502. doi:10.1016/j.jacbts.2023.10.005

Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model.

Iorgulescu B, Ruthen N, Ahn R, et al. Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model. Frontiers in immunology. 2023;14:1297932. doi:10.3389/fimmu.2023.1297932

Genotype imputation accuracy and the quality metrics of the minor ancestry in multi-ancestry reference panels.

Shi M, Tanikawa C, Munter HM, et al. Genotype imputation accuracy and the quality metrics of the minor ancestry in multi-ancestry reference panels. Briefings in bioinformatics. 2023;25(1). doi:10.1093/bib/bbad509

Unsupervised and supervised AI on molecular dynamics simulations reveals complex characteristics of HLA-A2-peptide immunogenicity.

Weber JK, Morrone JA, Kang SG, et al. Unsupervised and supervised AI on molecular dynamics simulations reveals complex characteristics of HLA-A2-peptide immunogenicity. Briefings in bioinformatics. 2023;25(1). doi:10.1093/bib/bbad504