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Publications

Laboratory evolution of a sortase enzyme that modifies amyloid-β protein.

Podracky CJ, An C, DeSousa A, Dorr BM, Walsh D, Liu DR. Laboratory evolution of a sortase enzyme that modifies amyloid-β protein. Nature chemical biology. 2021;17(3):317-325. doi:10.1038/s41589-020-00706-1

Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression.

Gao P, Lyu Q, Ghanam A, et al. Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression. Genome biology. 2021;22(1):83. doi:10.1186/s13059-021-02304-3

Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes.

Bick AG, Weinstock JS, Nandakumar SK, et al. Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2021;591(7851):E27. doi:10.1038/s41586-021-03280-1

Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1.

Tsai PY, Lee MS, Jadhav U, et al. Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proceedings of the National Academy of Sciences of the United States of America. 2021;118(10). doi:10.1073/pnas.2003014118

Role of dietary fiber in the recovery of the human gut microbiome and its metabolome.

Tanes C, Bittinger K, Gao Y, et al. Role of dietary fiber in the recovery of the human gut microbiome and its metabolome. Cell host & microbe. 2021;29(3):394-407.e5. doi:10.1016/j.chom.2020.12.012

Plasma Lipidomic Profiles and Risk of Diabetes: 2 Prospective Cohorts of HIV-Infected and HIV-Uninfected Individuals.

Zhang E, Chai JC, Deik AA, et al. Plasma Lipidomic Profiles and Risk of Diabetes: 2 Prospective Cohorts of HIV-Infected and HIV-Uninfected Individuals. The Journal of clinical endocrinology and metabolism. 2021;106(4):999-1010. doi:10.1210/clinem/dgab011

metabCombiner: Paired Untargeted LC-HRMS Metabolomics Feature Matching and Concatenation of Disparately Acquired Data Sets.

Habra H, Kachman M, Bullock K, Clish C, Evans CR, Karnovsky A. metabCombiner: Paired Untargeted LC-HRMS Metabolomics Feature Matching and Concatenation of Disparately Acquired Data Sets. Analytical chemistry. 2021;93(12):5028-5036. doi:10.1021/acs.analchem.0c03693

Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion.

Frangieh CJ, Melms JC, Thakore PI, et al. Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion. Nat Genet. 2021;53(3):332-341. doi:10.1038/s41588-021-00779-1

Genomic epidemiology of a Cryptococcus neoformans case cluster in Glasgow, Scotland, 2018.

Farrer RA, Borman AM, Inkster T, Fisher MC, Johnson EM, Cuomo CA. Genomic epidemiology of a Cryptococcus neoformans case cluster in Glasgow, Scotland, 2018. Microb Genom. 2021;7(3). doi:10.1099/mgen.0.000537

Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease.

Sidhom EH, Kim C, Kost-Alimova M, et al. Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease. J Clin Invest. 2021;131(5). doi:10.1172/JCI141380