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Publications

Cell type-specific genetic regulation of gene expression across human tissues.

Kim-Hellmuth S. Cell type-specific genetic regulation of gene expression across human tissues. Science (New York, N.Y.). 2020;369(6509). doi:10.1126/science.aaz8528

Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin.

Ma S. Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin. Cell. 2020;183(4):1103-1116.e20. doi:10.1016/j.cell.2020.09.056

Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis.

Kato S, Weng Q, Insco M, et al. Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis. Cancer discovery. 2020;10(7):980-997. doi:10.1158/2159-8290.CD-19-0532

A MicroRNA Linking Human Positive Selection and Metabolic Disorders.

Wang L, Sinnott-Armstrong N, Wagschal A, et al. A MicroRNA Linking Human Positive Selection and Metabolic Disorders. Cell. 2020;183(3):684-701.e14. doi:10.1016/j.cell.2020.09.017

Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling.

Roh HC, Kumari M, Taleb S, et al. Adipocytes fail to maintain cellular identity during obesity due to reduced PPARγ activity and elevated TGFβ-SMAD signaling. Molecular metabolism. 2020;42:101086. doi:10.1016/j.molmet.2020.101086

Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits.

Glastonbury CA, Pulit SL, Honecker J, et al. Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits. PLoS computational biology. 2020;16(8):e1008044. doi:10.1371/journal.pcbi.1008044

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.

Oguri Y, Shinoda K, Kim H, et al. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. 2020;182(3):563-577.e20. doi:10.1016/j.cell.2020.06.021

Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome.

Hsu YHH, Astley CM, Cole JB, et al. Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome. International journal of obesity (2005). 2020;44(7):1596-1606. doi:10.1038/s41366-020-0603-x

Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells.

Lee M, Maji B, Manna D, et al. Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells. Journal of the American Chemical Society. 2020;142(14):6477-6482. doi:10.1021/jacs.0c00099

Phosphorylation-Inducing Chimeric Small Molecules.

Siriwardena SU, Godage DNPM, Shoba VM, et al. Phosphorylation-Inducing Chimeric Small Molecules. Journal of the American Chemical Society. 2020;142(33):14052-14057. doi:10.1021/jacs.0c05537