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Center for the Development of Therapeutics

Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform.

Shaw S, Jiang W, Rush J, et al. Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform. iScience. 2025;28(3):112069. doi:10.1016/j.isci.2025.112069

Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes.

Ewald JD, Titterton KL, Bäuerle A, et al. Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.22.634152

A non-hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation.

Kabi M, Khamamkar A, Kyei-Baffour K, Weïwer M, Vijayaraghavan S, Dey S. A non-hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation. Andrology. 2025. doi:10.1111/andr.13838

nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome.

Dagher M, Ongo G, Robichaud N, et al. nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2023.04.17.535914

Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint.

Tsao HW, Anderson S, Finn KJ, et al. Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint. Immunity. 2024. doi:10.1016/j.immuni.2024.10.013

Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors.

Pecci F, Nakazawa S, Ricciuti B, et al. Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors. Cancer discovery. 2024. doi:10.1158/2159-8290.CD-23-1217

Mapping MAVE data for use in human genomics applications.

Arbesfeld JA, Da EY, Stevenson JS, et al. Mapping MAVE data for use in human genomics applications. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2023.06.20.545702

Scalable, compressed phenotypic screening using pooled perturbations.

Liu N, Kattan WE, Mead BE, et al. Scalable, compressed phenotypic screening using pooled perturbations. Nature biotechnology. 2024. doi:10.1038/s41587-024-02403-z

BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.

Meibom D, Wasnaire P, Beyer K, et al. BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor. Journal of medicinal chemistry. 2024. doi:10.1021/acs.jmedchem.3c02036

A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging.

Placzek MS, Wilton DK, Weïwer M, et al. A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging. ACS central science. 2024;10(5):1105-1114. doi:10.1021/acscentsci.3c01564