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Center for the Development of Therapeutics

Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen.

Poulsen BE, Warrier T, Barkho S, et al. Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen. Cell chemical biology. 2024. doi:10.1016/j.chembiol.2024.12.001

Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations.

Chandrasekaran SN, Cimini BA, Goodale A, et al. Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods. 2024. doi:10.1038/s41592-024-02241-6

Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers.

Rubinson DA, Tanaka N, de la Cruz FF, et al. Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers. Cancer discovery. 2024;14(5):727-736. doi:10.1158/2159-8290.CD-23-1138

Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors.

Pecci F, Nakazawa S, Ricciuti B, et al. Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors. Cancer discovery. 2024. doi:10.1158/2159-8290.CD-23-1217

The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS).

Jiang W, Soutter H. The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS). Journal of visualized experiments : JoVE. 2024;(203). doi:10.3791/65718

BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.

Meibom D, Wasnaire P, Beyer K, et al. BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor. Journal of medicinal chemistry. 2024. doi:10.1021/acs.jmedchem.3c02036

Protective role for kidney TREM2 macrophages in obesity- and diabetes-induced kidney injury.

Subramanian A, Vernon KA, Zhou Y, et al. Protective role for kidney TREM2 macrophages in obesity- and diabetes-induced kidney injury. Cell reports. 2024;43(6):114253. doi:10.1016/j.celrep.2024.114253

The benefits of translating biomedical research at drug discovery institutes.

Huggins DJ, Baell J, Brennan PE, Burgin A, Scott DE. The benefits of translating biomedical research at drug discovery institutes. Nature reviews. Drug discovery. 2024. doi:10.1038/d41573-024-00142-z

Delineation of functionally essential protein regions for 242 neurodevelopmental genes.

Iqbal S, Brünger T, Pérez-Palma E, et al. Delineation of functionally essential protein regions for 242 neurodevelopmental genes. Brain : a journal of neurology. 2023;146(2):519-533. doi:10.1093/brain/awac381

High-Throughput Neutralization and Serology Assays Reveal Correlated but Highly Variable Humoral Immune Responses in a Large Population of Individuals Infected with SARS-CoV-2 in the US between March and August 2020.

Zhang S, Ma P, Orzechowski M, et al. High-Throughput Neutralization and Serology Assays Reveal Correlated but Highly Variable Humoral Immune Responses in a Large Population of Individuals Infected with SARS-CoV-2 in the US between March and August 2020. mBio. 2023:e0352322. doi:10.1128/mbio.03523-22