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Center for the Development of Therapeutics

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.

Rush JS, Wertheimer JD, Goldberg SD, et al. Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity. Cell. 2026. doi:10.1016/j.cell.2025.12.013

Loss of Mtarc1 Protects Against Steatotic Liver Disease in Mice.

Yin X, Bickerton C, MacDonald B, et al. Loss of Mtarc1 Protects Against Steatotic Liver Disease in Mice. Liver international : official journal of the International Association for the Study of the Liver. 2026;46(2):e70507. doi:10.1111/liv.70507

nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome.

Dagher M, Ongo G, Robichaud N, et al. nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2023.04.17.535914

Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis.

Haj AK, Paul DS, Jurgens SJ, et al. Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis. Nature communications. 2025;16(1):8176. doi:10.1038/s41467-025-62789-5

Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform.

Shaw S, Jiang W, Rush J, et al. Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform. iScience. 2025;28(3):112069. doi:10.1016/j.isci.2025.112069

Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes.

Ewald JD, Titterton KL, Bäuerle A, et al. Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.01.22.634152

A non-hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation.

Kabi M, Khamamkar A, Kyei-Baffour K, Weïwer M, Vijayaraghavan S, Dey S. A non-hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation. Andrology. 2025. doi:10.1111/andr.13838

A generative deep learning approach to de novo antibiotic design.

Krishnan A. A generative deep learning approach to de novo antibiotic design. Cell. 2025. doi:10.1016/j.cell.2025.07.033

The OASIS Consortium: Integrating Multi-Omics Technologies to Transform Chemical Safety Assessment.

Rouquié D, Bender A, Cheah J, et al. The OASIS Consortium: Integrating Multi-Omics Technologies to Transform Chemical Safety Assessment. Toxicological sciences : an official journal of the Society of Toxicology. 2025. doi:10.1093/toxsci/kfaf128

Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype.

Samokhin AO, Seo HS, Leed A, et al. Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.07.10.663547