Liu N, Kattan WE, Mead BE, et al. Scalable, compressed phenotypic screening using pooled perturbations. Nature biotechnology. 2024. doi:10.1038/s41587-024-02403-z
Center for the Development of Therapeutics
Meibom D, Wasnaire P, Beyer K, et al. BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor. Journal of medicinal chemistry. 2024. doi:10.1021/acs.jmedchem.3c02036
Placzek MS, Wilton DK, Weïwer M, et al. A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging. ACS central science. 2024;10(5):1105-1114. doi:10.1021/acscentsci.3c01564
Khandelwal NK, Gupta M, Gomez JE, et al. Structure and inhibition mechanisms of essential transporter efflux protein A. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.09.04.611325
Babbe H, Sundberg TB, Tichenor M, et al. Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(1):e2307086120. doi:10.1073/pnas.2307086120
Subramanian A, Vernon KA, Zhou Y, et al. Protective role for kidney TREM2 macrophages in obesity- and diabetes-induced kidney injury. Cell reports. 2024;43(6):114253. doi:10.1016/j.celrep.2024.114253
Kwon S, Safer J, Nguyen DT, et al. Genomics 2 Proteins portal: a resource and discovery tool for linking genetic screening outputs to protein sequences and structures. Nature methods. 2024. doi:10.1038/s41592-024-02409-0
Poulsen BE, Warrier T, Barkho S, et al. Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen. Cell chemical biology. 2024. doi:10.1016/j.chembiol.2024.12.001
Rubinson DA, Tanaka N, de la Cruz FF, et al. Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers. Cancer discovery. 2024;14(5):727-736. doi:10.1158/2159-8290.CD-23-1138
Jiang W, Soutter H. The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS). Journal of visualized experiments : JoVE. 2024;(203). doi:10.3791/65718