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Center for the Development of Therapeutics

High-Throughput Assay to Screen Small Molecules for Their Ability to Prevent Sickling of Red Blood Cells.

Nakagawa A, Cooper MK, Kost-Alimova M, et al. High-Throughput Assay to Screen Small Molecules for Their Ability to Prevent Sickling of Red Blood Cells. ACS Omega. 2022;7(16):14009-14016. doi:10.1021/acsomega.2c00541

Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity.

Small JC, Joblin-Mills A, Carbone K, et al. Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity. ACS Chem Biol. 2022. doi:10.1021/acschembio.2c00052

Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer.

Bondeson DP, Paolella BR, Asfaw A, et al. Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. Nat Cancer. 2022. doi:10.1038/s43018-022-00360-7

A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives.

Li Y, Wei L, Meinsohn MC, et al. A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives. Proc Natl Acad Sci U S A. 2022;119(15):e2122512119. doi:10.1073/pnas.2122512119

Circuit topology predicts pathogenicity of missense mutations.

Woodard J, Iqbal S, Mashaghi A. Circuit topology predicts pathogenicity of missense mutations. Proteins. 2022. doi:10.1002/prot.26342

TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease.

MacDonald BT, Keshishian H, Mundorff CC, et al. TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease. Mol Cell Proteomics. 2022;21(4):100223. doi:10.1016/j.mcpro.2022.100223

Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators.

Zhang YL, Moran SP, Allen A, et al. Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators. ACS Pharmacol Transl Sci. 2022;5(3):156-168. doi:10.1021/acsptsci.1c00233

Characterization of intrinsically disordered regions in proteins informed by human genetic diversity.

Ahmed SS, Rifat ZT, Lohia R, et al. Characterization of intrinsically disordered regions in proteins informed by human genetic diversity. PLoS Comput Biol. 2022;18(3):e1009911. doi:10.1371/journal.pcbi.1009911

Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.

Kwon J, Hajian B, Bian Y, et al. Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature. 2022;609(7926):408-415. doi:10.1038/s41586-022-04928-2

Morphology and gene expression profiling provide complementary information for mapping cell state.

Way G, Natoli T, Adeboye A, et al. Morphology and gene expression profiling provide complementary information for mapping cell state. Cell systems. 2022;13(11):911-923.e9. doi:10.1016/j.cels.2022.10.001