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Center for the Development of Therapeutics

Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.

Babbe H, Sundberg TB, Tichenor M, et al. Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(1):e2307086120. doi:10.1073/pnas.2307086120

Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint.

Tsao HW, Anderson S, Finn KJ, et al. Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint. Immunity. 2024. doi:10.1016/j.immuni.2024.10.013

Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations.

Chandrasekaran SN, Cimini BA, Goodale A, et al. Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods. 2024. doi:10.1038/s41592-024-02241-6

Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors.

Pecci F, Nakazawa S, Ricciuti B, et al. Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors. Cancer discovery. 2024. doi:10.1158/2159-8290.CD-23-1217

The benefits of translating biomedical research at drug discovery institutes.

Huggins DJ, Baell J, Brennan PE, Burgin A, Scott DE. The benefits of translating biomedical research at drug discovery institutes. Nature reviews. Drug discovery. 2024. doi:10.1038/d41573-024-00142-z

Mapping MAVE data for use in human genomics applications.

Arbesfeld JA, Da EY, Stevenson JS, et al. Mapping MAVE data for use in human genomics applications. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2023.06.20.545702

Genomics 2 Proteins portal: a resource and discovery tool for linking genetic screening outputs to protein sequences and structures.

Kwon S, Safer J, Nguyen DT, et al. Genomics 2 Proteins portal: a resource and discovery tool for linking genetic screening outputs to protein sequences and structures. Nature methods. 2024. doi:10.1038/s41592-024-02409-0

Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors.

Bazua-Valenti S, Brown MR, Zavras J, et al. Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors. The Journal of clinical investigation. 2024;134(24). doi:10.1172/JCI180347

Protective role for kidney TREM2 macrophages in obesity- and diabetes-induced kidney injury.

Subramanian A, Vernon KA, Zhou Y, et al. Protective role for kidney TREM2 macrophages in obesity- and diabetes-induced kidney injury. Cell reports. 2024;43(6):114253. doi:10.1016/j.celrep.2024.114253

Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers.

Rubinson DA, Tanaka N, de la Cruz FF, et al. Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers. Cancer discovery. 2024;14(5):727-736. doi:10.1158/2159-8290.CD-23-1138