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Center for the Development of Therapeutics

Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations

Chandrasekaran SN, Cimini BA, Goodale A, et al. Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. bioRxiv. 2022. doi:10.1101/2022.01.05.475090

Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket.

Fernando DM, Gee CT, Griffith EC, et al. Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket. Tuberculosis (Edinb). 2022;132:102157. doi:10.1016/j.tube.2021.102157

Identification of Inhibitors of Fungal Fatty Acid Biosynthesis.

DeJarnette C, Meyer CJ, Jenner AR, et al. Identification of Inhibitors of Fungal Fatty Acid Biosynthesis. ACS Infect Dis. 2021;7(12):3210-3223. doi:10.1021/acsinfecdis.1c00404

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

Ito T, Young MJ, Li R, et al. Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Nat Genet. 2021;53(12):1664-1672. doi:10.1038/s41588-021-00967-z

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.

Wang JS, Kamath T, Mazur CM, et al. Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin. Nat Commun. 2021;12(1):6271. doi:10.1038/s41467-021-26571-7

Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses.

Wang M, Lee-Kim VS, Atri DS, et al. Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses. Circ Genom Precis Med. 2021;14(5):e003399. doi:10.1161/CIRCGEN.121.003399

Molecular basis for substrate recruitment to the PRMT5 methylosome.

Mulvaney KM, Blomquist C, Acharya N, et al. Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol Cell. 2021;81(17):3481-3495.e7. doi:10.1016/j.molcel.2021.07.019

Coronary Disease Association With ADAMTS7 Is Due to Protease Activity.

Mizoguchi T, MacDonald BT, Bhandary B, et al. Coronary Disease Association With ADAMTS7 Is Due to Protease Activity. Circ Res. 2021;129(4):458-470. doi:10.1161/CIRCRESAHA.121.319163

SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations.

Margiotta E, Guerra CF. SARS-CoV spike proteins can compete for electrolytes in physiological fluids according to structure-based quantum-chemical calculations. Comput Theor Chem. 2021:113392. doi:10.1016/j.comptc.2021.113392

Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.

McKinney DC, McMillan BJ, Ranaghan MJ, et al. Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J Med Chem. 2021. doi:10.1021/acs.jmedchem.1c00507