Nakagawa A, Cooper MK, Kost-Alimova M, et al. High-Throughput Assay to Screen Small Molecules for Their Ability to Prevent Sickling of Red Blood Cells. ACS Omega. 2022;7(16):14009-14016. doi:10.1021/acsomega.2c00541
Center for the Development of Therapeutics
Small JC, Joblin-Mills A, Carbone K, et al. Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity. ACS Chem Biol. 2022. doi:10.1021/acschembio.2c00052
Bondeson DP, Paolella BR, Asfaw A, et al. Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. Nat Cancer. 2022. doi:10.1038/s43018-022-00360-7
Li Y, Wei L, Meinsohn MC, et al. A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives. Proc Natl Acad Sci U S A. 2022;119(15):e2122512119. doi:10.1073/pnas.2122512119
Woodard J, Iqbal S, Mashaghi A. Circuit topology predicts pathogenicity of missense mutations. Proteins. 2022. doi:10.1002/prot.26342
MacDonald BT, Keshishian H, Mundorff CC, et al. TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease. Mol Cell Proteomics. 2022;21(4):100223. doi:10.1016/j.mcpro.2022.100223
Zhang YL, Moran SP, Allen A, et al. Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators. ACS Pharmacol Transl Sci. 2022;5(3):156-168. doi:10.1021/acsptsci.1c00233
Ahmed SS, Rifat ZT, Lohia R, et al. Characterization of intrinsically disordered regions in proteins informed by human genetic diversity. PLoS Comput Biol. 2022;18(3):e1009911. doi:10.1371/journal.pcbi.1009911
Miller P, Sathappa M, Moroco J, et al. Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state. Nature communications. 2022;13(1):3778. doi:10.1038/s41467-022-30463-9
Shekhar M, Gupta C, Suzuki K, Chan C, Murata T, Singharoy A. Revealing a Hidden Intermediate of Rotatory Catalysis with X-ray Crystallography and Molecular Simulations. ACS central science. 2022;8(7):915-925. doi:10.1021/acscentsci.1c01599