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Metabolomics Platform

Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells.

Sanmarco LM, Rone JM, Polonio CM, et al. Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.17.532101

Tryptophan metabolism, gut microbiota, and carotid artery plaque in women with and without HIV infection.

Luo K, Wang Z, Peters BA, et al. Tryptophan metabolism, gut microbiota, and carotid artery plaque in women with and without HIV infection. AIDS (London, England). 2023. doi:10.1097/QAD.0000000000003596

Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank.

Zeleznik OA, Kang JH, Lasky-Su J, et al. Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank. Nature communications. 2023;14(1):2860. doi:10.1038/s41467-023-38466-w

Inflammatory Bowel Disease Is Associated With Prediagnostic Perturbances in Metabolic Pathways.

Hua X, Ungaro RC, Petrick LM, et al. Inflammatory Bowel Disease Is Associated With Prediagnostic Perturbances in Metabolic Pathways. Gastroenterology. 2023;164(1):147-150.e2. doi:10.1053/j.gastro.2022.09.007

Clonal haematopoiesis and risk of chronic liver disease.

Wong WJ, Emdin C, Bick AG, et al. Clonal haematopoiesis and risk of chronic liver disease. Nature. 2023;616(7958):747-754. doi:10.1038/s41586-023-05857-4

Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial.

Toledo E, Wittenbecher C, Razquin C, et al. Plasma lipidome and risk of atrial fibrillation: results from the PREDIMED trial. Journal of physiology and biochemistry. 2023. doi:10.1007/s13105-023-00958-0

Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis.

Ardiansyah E, Avila-Pacheco J, Nhat LTH, et al. Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis. eLife. 2023;12. doi:10.7554/eLife.85307

Circulating citric acid cycle metabolites and risk of cardiovascular disease in the PREDIMED study.

Santos JL, Ruiz-Canela M, Razquin C, et al. Circulating citric acid cycle metabolites and risk of cardiovascular disease in the PREDIMED study. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2023;33(4):835-843. doi:10.1016/j.numecd.2023.01.002

Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis.

Cronjé HT, Mi MY, Austin TR, et al. Plasma proteomic risk markers of incident type 2 diabetes reflect physiologically distinct components of glucose-insulin homeostasis. Diabetes. 2023;72(5):666-73. doi:10.2337/db22-0628

Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis.

Zhou W, Simic P, Zhou IY, et al. Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis. The Journal of clinical investigation. 2023;133(8). doi:10.1172/JCI164610