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Metabolomics Platform

Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies.

Tessier AJ, Wang F, Liang L, et al. Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies. Med (New York, N.Y.). 2024. doi:10.1016/j.medj.2024.01.010

Tryptophan metabolism, gut microbiota, and carotid artery plaque in women with and without HIV infection.

Luo K, Wang Z, Peters BA, et al. Tryptophan metabolism, gut microbiota, and carotid artery plaque in women with and without HIV infection. AIDS (London, England). 2023. doi:10.1097/QAD.0000000000003596

Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals.

Wang F, Tessier AJ, Liang L, et al. Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals. Nature communications. 2023;14(1):5744. doi:10.1038/s41467-023-41515-z

A Plasma Metabolite Score Related to Psychological Distress and Diabetes Risk: A Nested Case-control Study in US Women.

Huang T, Zhu Y, Shutta KH, et al. A Plasma Metabolite Score Related to Psychological Distress and Diabetes Risk: A Nested Case-control Study in US Women. The Journal of clinical endocrinology and metabolism. 2023. doi:10.1210/clinem/dgad731

Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis.

Zhou W, Simic P, Zhou IY, et al. Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis. The Journal of clinical investigation. 2023;133(8). doi:10.1172/JCI164610

Sleep duration, plasma metabolites, and obesity and diabetes: a metabolome-wide association study in US women.

Fritz J, Huang T, Depner CM, et al. Sleep duration, plasma metabolites, and obesity and diabetes: a metabolome-wide association study in US women. Sleep. 2023;46(1). doi:10.1093/sleep/zsac226

Effectors enabling adaptation to mitochondrial complex I loss in Hurthle cell carcinoma.

Gopal RK, Vantaku VR, Panda A, et al. Effectors enabling adaptation to mitochondrial complex I loss in Hurthle cell carcinoma. Cancer discovery. 2023. doi:10.1158/2159-8290.CD-22-0976

The functional impact of rare variation across the regulatory cascade.

Li T, Ferraro N, Strober BJ, et al. The functional impact of rare variation across the regulatory cascade. Cell genomics. 2023;3(10):100401. doi:10.1016/j.xgen.2023.100401

Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis.

Moreau F, Brunao BB, Liu XY, et al. Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis. Journal of lipid research. 2023;64(2):100324. doi:10.1016/j.jlr.2022.100324

Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells.

Sanmarco LM, Rone JM, Polonio CM, et al. Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells. Nature. 2023. doi:10.1038/s41586-023-06409-6