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Proteomics Platform

Mass spectrometry-based profiling of single-cell histone post-translational modifications to dissect chromatin heterogeneity.

Cutler R, Corveleyn L, Ctortecka C, et al. Mass spectrometry-based profiling of single-cell histone post-translational modifications to dissect chromatin heterogeneity. Nature communications. 2025;16(1):11100. doi:10.1038/s41467-025-66031-0

Integrative proteogenomics and forward genetics reveals a novel mitotic vulnerability in triple-negative breast cancer.

Neill NJ, Satpathy S, Krug K, et al. Integrative proteogenomics and forward genetics reveals a novel mitotic vulnerability in triple-negative breast cancer. Cancer discovery. 2025. doi:10.1158/2159-8290.CD-23-1173

Targeting of HIF2-driven cachexia in kidney cancer.

Abu-Remaileh M, Stransky LA, Bhalerao N, et al. Targeting of HIF2-driven cachexia in kidney cancer. Nature medicine. 2025. doi:10.1038/s41591-025-04054-2

Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures.

Satpathy S, Clark NM, Chen YJ, et al. Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures. Cancer cell. 2025. doi:10.1016/j.ccell.2025.07.011

High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissues.

Haines M, Thorup JR, Gohsman S, et al. High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissues. Molecular & cellular proteomics : MCP. 2025:101044. doi:10.1016/j.mcpro.2025.101044

Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway.

Xiao L, Pi X, Goss AC, et al. Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway. Science advances. 2024;10(38):eadp2221. doi:10.1126/sciadv.adp2221

Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation.

Cieri N, Hookeri N, Stromhaug K, et al. Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation. Nature biotechnology. 2024. doi:10.1038/s41587-024-02348-3

Automated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications.

Ctortecka C, Clark NM, Boyle B, et al. Automated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.01.20.576369

Cell-surface Milieu Remodeling in Human Dendritic Cell Activation.

Udeshi ND, Xu C, Jiang Z, et al. Cell-surface Milieu Remodeling in Human Dendritic Cell Activation. Journal of immunology (Baltimore, Md. : 1950). 2024. doi:10.4049/jimmunol.2400089

IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response.

Simpson MS, De Luca H, Cauthorn S, et al. IRE1α recognizes a structural motif in cholera toxin to activate an unfolded protein response. The Journal of cell biology. 2024;223(7). doi:10.1083/jcb.202402062