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Proteomics Platform

Chromatin regulator SMARCAL1 modulates cellular lipid metabolism.

Nagai TH, Hartigan C, Mizoguchi T, et al. Chromatin regulator SMARCAL1 modulates cellular lipid metabolism. Communications biology. 2023;6(1):1298. doi:10.1038/s42003-023-05665-6

Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.

Aryal S, Bonanno K, Song B, et al. Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model. Cell reports. 2023;42(5):112497. doi:10.1016/j.celrep.2023.112497

An automated nanowell-array workflow for quantitative multiplexed single-cell proteomics sample preparation at high sensitivity.

Ctortecka C, Hartlmayr D, Seth A, et al. An automated nanowell-array workflow for quantitative multiplexed single-cell proteomics sample preparation at high sensitivity. Molecular & cellular proteomics : MCP. 2023:100665. doi:10.1016/j.mcpro.2023.100665

Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies.

Yin S, Klaeger S, Chea VA, et al. Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies. Frontiers in immunology. 2023;14:1269335. doi:10.3389/fimmu.2023.1269335

Pan-viral ORFs discovery using Massively Parallel Ribosome Profiling.

Weingarten-Gabbay S, Bauer MR, Stanton AC, et al. Pan-viral ORFs discovery using Massively Parallel Ribosome Profiling. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.09.26.559641

A ubiquitination cascade regulating the integrated stress response and survival in carcinomas.

Cervia LD, Shibue T, Borah AA, et al. A ubiquitination cascade regulating the integrated stress response and survival in carcinomas. Cancer Discov. 2022. doi:10.1158/2159-8290.CD-22-1230

HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses.

Weingarten-Gabbay S, Pearlman LR, Chen DY, et al. HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses. STAR Protoc. 2022;3(4):101910. doi:10.1016/j.xpro.2022.101910

In situ cell-type-specific cell-surface proteomic profiling in mice.

Shuster A, Li J, Chon U, et al. In situ cell-type-specific cell-surface proteomic profiling in mice. Neuron. 2022;110(23):3882-3896.e9. doi:10.1016/j.neuron.2022.09.025

CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response.

Jutzi JS, Marneth AE, Jiménez-Santos MJ, et al. CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response. Leukemia. 2022. doi:10.1038/s41375-022-01781-0

Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer.

Anurag M, Jaehnig EJ, Krug K, et al. Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer. Cancer Discov. 2022;12(11):2586-2605. doi:10.1158/2159-8290.CD-22-0200