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Proteomics Platform

Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production.

Xu J, Kong L, Oliver BA, et al. Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production. Cell reports. 2023;42(7):112708. doi:10.1016/j.celrep.2023.112708

Protein phosphatase 1 regulates core PCP signaling.

Song S, Cho B, Weiner AT, et al. Protein phosphatase 1 regulates core PCP signaling. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.09.12.556998

Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation.

Geffen Y, Anand S, Akiyama Y, et al. Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation. Cell. 2023. doi:10.1016/j.cell.2023.07.013

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

Schmidt N, Ganskih S, Wei Y, et al. SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9. Cell. 2023. doi:10.1016/j.cell.2023.09.002

Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies.

Yin S, Klaeger S, Chea VA, et al. Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies. Frontiers in immunology. 2023;14:1269335. doi:10.3389/fimmu.2023.1269335

Protein phosphatase 1 regulates core PCP signaling.

Song S, Cho B, Weiner AT, et al. Protein phosphatase 1 regulates core PCP signaling. EMBO reports. 2023;24(12):e56997. doi:10.15252/embr.202356997

Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.

Aryal S, Bonanno K, Song B, et al. Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model. Cell reports. 2023;42(5):112497. doi:10.1016/j.celrep.2023.112497

HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery.

Stražar M, Park J, Abelin JG, et al. HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery. Immunity. 2023. doi:10.1016/j.immuni.2023.05.009

Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Abelin J, Bergstrom E, Rivera K, et al. Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues. Nature communications. 2023;14(1):1851. doi:10.1038/s41467-023-37547-0

An automated nanowell-array workflow for quantitative multiplexed single-cell proteomics sample preparation at high sensitivity.

Ctortecka C, Hartlmayr D, Seth A, et al. An automated nanowell-array workflow for quantitative multiplexed single-cell proteomics sample preparation at high sensitivity. Molecular & cellular proteomics : MCP. 2023:100665. doi:10.1016/j.mcpro.2023.100665