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Proteomics Platform

An automated nanowell-array workflow for quantitative multiplexed single-cell proteomics sample preparation at high sensitivity.

Ctortecka C, Hartlmayr D, Seth A, et al. An automated nanowell-array workflow for quantitative multiplexed single-cell proteomics sample preparation at high sensitivity. Molecular & cellular proteomics : MCP. 2023:100665. doi:10.1016/j.mcpro.2023.100665

Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Abelin J, Bergstrom E, Rivera K, et al. Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues. Nature communications. 2023;14(1):1851. doi:10.1038/s41467-023-37547-0

Protein phosphatase 1 regulates core PCP signaling.

Song S, Cho B, Weiner AT, et al. Protein phosphatase 1 regulates core PCP signaling. EMBO reports. 2023;24(12):e56997. doi:10.15252/embr.202356997

LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma.

Sato S, Gillette M, de Santiago P, et al. LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma. Scientific reports. 2023;13(1):1537. doi:10.1038/s41598-023-28840-5

Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production.

Xu J, Kong L, Oliver BA, et al. Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production. Cell reports. 2023;42(7):112708. doi:10.1016/j.celrep.2023.112708

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

Schmidt N, Ganskih S, Wei Y, et al. SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9. Cell. 2023. doi:10.1016/j.cell.2023.09.002

Chromatin regulator SMARCAL1 modulates cellular lipid metabolism.

Nagai TH, Hartigan C, Mizoguchi T, et al. Chromatin regulator SMARCAL1 modulates cellular lipid metabolism. Communications biology. 2023;6(1):1298. doi:10.1038/s42003-023-05665-6

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling.

Gentili M, Liu B, Papanastasiou M, et al. ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling. Nature communications. 2023;14(1):611. doi:10.1038/s41467-023-36132-9

A ubiquitination cascade regulating the integrated stress response and survival in carcinomas.

Cervia LD, Shibue T, Borah AA, et al. A ubiquitination cascade regulating the integrated stress response and survival in carcinomas. Cancer Discov. 2022. doi:10.1158/2159-8290.CD-22-1230

HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses.

Weingarten-Gabbay S, Pearlman LR, Chen DY, et al. HLA-I immunopeptidome profiling of human cells infected with high-containment enveloped viruses. STAR Protoc. 2022;3(4):101910. doi:10.1016/j.xpro.2022.101910