Dippon VN, Rizvi Z, Choudhry AE, et al. Identification of an allosteric site on the E3 ligase adapter cereblon. Nature. 2026. doi:10.1038/s41586-025-09994-w
Chemical Biology and Therapeutics Science Program
Halim S, Sebastian RM, Liivak KE, et al. Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network. Molecular cell. 2026. doi:10.1016/j.molcel.2025.12.013
Raval S, Shi Y, Morriss JW, et al. Nano-scaled, fully automated hydrogen/deuterium exchange for analysis of macromolecular assemblies reaching the MDa scale. Molecular & cellular proteomics : MCP. 2026:101519. doi:10.1016/j.mcpro.2026.101519
Singh S, Tran K, Karaj E, et al. Lysine Targeting Group-Transfer Chimeras for Proximity Induction. Angewandte Chemie (International ed. in English). 2026:e12131. doi:10.1002/anie.202512131
Waterbury AL, Iram I, Liau BB. Building the first base editors. Nature chemical biology. 2025;21(1):16-17. doi:10.1038/s41589-024-01790-3
Yu R, Roseman S, Siegenfeld AP, et al. CTCF/RAD21 organize the ground state of chromatin-nuclear speckle association. Nature structural & molecular biology. 2025. doi:10.1038/s41594-024-01465-6
Waterbury AL, Caroli J, Zhang O, et al. Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Nature communications. 2025;16(1):3156. doi:10.1038/s41467-025-57477-3
Lloyd HC, Li Y, Payne C, et al. A method for the detection and enrichment of endogenous cereblon substrates. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.03.24.645063
Yeo MJR, Zhang O, Xie X, et al. UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors. Nature. 2025. doi:10.1038/s41586-024-08532-4
Zhang J, Ali MY, Chong HB, et al. Oxidation of retromer complex controls mitochondrial translation. Nature. 2025. doi:10.1038/s41586-025-08756-y