Joynt AT, Kavanagh EW, Newby GA, et al. Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells. Molecular therapy. Nucleic acids. 2023;33:335-350. doi:10.1016/j.omtn.2023.06.020
Chemical Biology and Therapeutics Science Program
Garcia EM, Lue NZ, Liang JK, et al. Base Editor Scanning Reveals Activating Mutations of DNMT3A. ACS chemical biology. 2023. doi:10.1021/acschembio.3c00257
Sreekanth V, Jan M, Zhao KT, et al. A molecular glue approach to control the half-life of CRISPR-based technologies. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.03.12.531757
Cooney AL, Brommel CM, Traore S, et al. Reciprocal mutations of lung-tropic AAV capsids lead to improved transduction properties. Frontiers in genome editing. 2023;5:1271813. doi:10.3389/fgeed.2023.1271813
Kulhankova K, Traore S, Cheng X, et al. Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo. Nature communications. 2023;14(1):8051. doi:10.1038/s41467-023-43904-w
Gibson WJ, Sadagopan A, Shoba VM, Choudhary A, Meyerson M, Schreiber SL. Bifunctional Small Molecules That Induce Nuclear Localization and Targeted Transcriptional Regulation. Journal of the American Chemical Society. 2023;145(48):26028-26037. doi:10.1021/jacs.3c06179
Arp CJ, Reynders M, Sreekanth V, et al. Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.04.09.536172
Arp CJ, Reynders M, Sreekanth V, et al. Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.04.09.536172
Li H, Ma T, Remsberg JR, et al. Assigning functionality to cysteines by base editing of cancer dependency genes. Nature chemical biology. 2023. doi:10.1038/s41589-023-01428-w
Doman JL, Pandey S, Neugebauer ME, et al. Phage-assisted evolution and protein engineering yield compact, efficient prime editors. Cell. 2023;186(18):3983-4002.e26. doi:10.1016/j.cell.2023.07.039