ӳ��ý

Chemical Biology and Therapeutics Science Program

An ingestible capsule for luminance-based diagnosis of mesenteric ischemia.

Chen J, Alexiev A, Sergnese A, et al. An ingestible capsule for luminance-based diagnosis of mesenteric ischemia. Science robotics. 2025;10(107):eadx1367. doi:10.1126/scirobotics.adx1367

Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing.

Pandey S, Gao XD, Krasnow NA, et al. Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing. Nature biomedical engineering. 2024. doi:10.1038/s41551-024-01227-1

High-throughput evaluation of genetic variants with prime editing sensor libraries.

Gould SI, Wuest AN, Dong K, et al. High-throughput evaluation of genetic variants with prime editing sensor libraries. Nature biotechnology. 2024. doi:10.1038/s41587-024-02172-9

Branched chemically modified poly(A) tails enhance the translation capacity of mRNA.

Chen H, Liu D, Guo J, et al. Branched chemically modified poly(A) tails enhance the translation capacity of mRNA. Nature biotechnology. 2024. doi:10.1038/s41587-024-02174-7

Twin prime editing mediated exon skipping/reinsertion for restored collagen VII expression in recessive dystrophic epidermolysis bullosa.

Steinbeck BJ, Gao XD, McElroy AN, et al. Twin prime editing mediated exon skipping/reinsertion for restored collagen VII expression in recessive dystrophic epidermolysis bullosa. The Journal of investigative dermatology. 2024. doi:10.1016/j.jid.2024.04.013

EvoAI enables extreme compression and reconstruction of the protein sequence space.

Ma Z, Li W, Shen Y, et al. EvoAI enables extreme compression and reconstruction of the protein sequence space. Nature methods. 2024. doi:10.1038/s41592-024-02504-2

Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput.

Kennedy PH, Sheikh AAD, Balakar M, et al. Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput. Nature methods. 2024. doi:10.1038/s41592-024-02256-z

Introducing a G-Makassar variant in HSCs by in vivo base editing treats sickle cell disease in mice.

Li C, Georgakopoulou A, Paschoudi K, et al. Introducing a G-Makassar variant in HSCs by in vivo base editing treats sickle cell disease in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2024. doi:10.1016/j.ymthe.2024.10.018

Directed evolution of engineered virus-like particles with improved production and transduction efficiencies.

Raguram A, An M, Chen PZ, Liu DR. Directed evolution of engineered virus-like particles with improved production and transduction efficiencies. Nature biotechnology. 2024. doi:10.1038/s41587-024-02467-x

Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo.

An M, Raguram A, Du SW, et al. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology. 2024. doi:10.1038/s41587-023-02078-y