ӳ��ý

Chemical Biology and Therapeutics Science Program

DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.

Takahashi M, Chong HB, Zhang S, et al. DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024. doi:10.1016/j.cell.2024.03.027

Branched chemically modified poly(A) tails enhance the translation capacity of mRNA.

Chen H, Liu D, Guo J, et al. Branched chemically modified poly(A) tails enhance the translation capacity of mRNA. Nature biotechnology. 2024. doi:10.1038/s41587-024-02174-7

Twin prime editing mediated exon skipping/reinsertion for restored collagen VII expression in recessive dystrophic epidermolysis bullosa.

Steinbeck BJ, Gao XD, McElroy AN, et al. Twin prime editing mediated exon skipping/reinsertion for restored collagen VII expression in recessive dystrophic epidermolysis bullosa. The Journal of investigative dermatology. 2024. doi:10.1016/j.jid.2024.04.013

EvoAI enables extreme compression and reconstruction of the protein sequence space.

Ma Z, Li W, Shen Y, et al. EvoAI enables extreme compression and reconstruction of the protein sequence space. Nature methods. 2024. doi:10.1038/s41592-024-02504-2

Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput.

Kennedy PH, Sheikh AAD, Balakar M, et al. Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput. Nature methods. 2024. doi:10.1038/s41592-024-02256-z

Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells.

Sousa AA, Hemez C, Lei L, et al. Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells. Nature biomedical engineering. 2024. doi:10.1038/s41551-024-01233-3

Introducing a G-Makassar variant in HSCs by in vivo base editing treats sickle cell disease in mice.

Li C, Georgakopoulou A, Paschoudi K, et al. Introducing a G-Makassar variant in HSCs by in vivo base editing treats sickle cell disease in mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2024. doi:10.1016/j.ymthe.2024.10.018

Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference.

Zhang E, Neugebauer ME, Krasnow NA, Liu DR. Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference. Nature communications. 2024;15(1):1697. doi:10.1038/s41467-024-45969-7

Directed evolution of engineered virus-like particles with improved production and transduction efficiencies.

Raguram A, An M, Chen PZ, Liu DR. Directed evolution of engineered virus-like particles with improved production and transduction efficiencies. Nature biotechnology. 2024. doi:10.1038/s41587-024-02467-x

Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo.

An M, Raguram A, Du SW, et al. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology. 2024. doi:10.1038/s41587-023-02078-y