Witte IP, Lampe GD, Eitzinger S, et al. Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase. Science (New York, N.Y.). 2025;388(6748):eadt5199. doi:10.1126/science.adt5199
Chemical Biology and Therapeutics Science Program
Waterbury AL, Iram I, Liau BB. Building the first base editors. Nature chemical biology. 2025;21(1):16-17. doi:10.1038/s41589-024-01790-3
Zhang J, Ali MY, Chong HB, et al. Oxidation of retromer complex controls mitochondrial translation. Nature. 2025. doi:10.1038/s41586-025-08756-y
Xie X, Zhang O, Yeo MJR, et al. Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations. Nature. 2025. doi:10.1038/s41586-024-08533-3
Vera AO, Truex NL, Sreekanth V, Pentelute BL, Choudhary A, Raines RT. Protective antigen-mediated delivery of an anti-CRISPR protein for precision genome editing. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(32):e2426960122. doi:10.1073/pnas.2426960122
Yu R, Roseman S, Siegenfeld AP, et al. CTCF/RAD21 organize the ground state of chromatin-nuclear speckle association. Nature structural & molecular biology. 2025. doi:10.1038/s41594-024-01465-6
Waterbury AL, Caroli J, Zhang O, et al. Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Nature communications. 2025;16(1):3156. doi:10.1038/s41467-025-57477-3
Khirallah J, Bloomer H, Wich D, et al. In vivo base editing of Angptl3 via lipid nanoparticles to treat cardiovascular disease. Molecular therapy. Nucleic acids. 2025;36(2):102486. doi:10.1016/j.omtn.2025.102486
Pergu R, Vedagopuram S, Kokkonda P, et al. Phosphorylation-inducing molecules for regulating dynamic cellular processes. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.05.10.652895
Vedagopuram S, Sindi S, Chaudhary S, et al. Ultrasmall chemogenetic tags with group-transfer ligands. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.05.10.653252