An M, Davis JR, Levy JM, et al. In vivo base editing extends lifespan of a humanized mouse model of prion disease. Nature medicine. 2025. doi:10.1038/s41591-024-03466-w
Chemical Biology and Therapeutics Science Program
Yu R, Roseman S, Siegenfeld AP, et al. CTCF/RAD21 organize the ground state of chromatin-nuclear speckle association. Nature structural & molecular biology. 2025. doi:10.1038/s41594-024-01465-6
Witte IP, Lampe GD, Eitzinger S, et al. Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase. Science (New York, N.Y.). 2025;388(6748):eadt5199. doi:10.1126/science.adt5199
Du SW, Newby GA, Salom D, et al. In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(48):e2416827121. doi:10.1073/pnas.2416827121
Gould SI, Wuest AN, Dong K, et al. High-throughput evaluation of genetic variants with prime editing sensor libraries. Nature biotechnology. 2024. doi:10.1038/s41587-024-02172-9
Kennedy PH, Sheikh AAD, Balakar M, et al. Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput. Nature methods. 2024. doi:10.1038/s41592-024-02256-z
Zhang E, Neugebauer ME, Krasnow NA, Liu DR. Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference. Nature communications. 2024;15(1):1697. doi:10.1038/s41467-024-45969-7
Pandey S, Gao XD, Krasnow NA, et al. Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing. Nature biomedical engineering. 2024. doi:10.1038/s41551-024-01227-1
Raguram A, An M, Chen PZ, Liu DR. Directed evolution of engineered virus-like particles with improved production and transduction efficiencies. Nature biotechnology. 2024. doi:10.1038/s41587-024-02467-x
An M, Raguram A, Du SW, et al. Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology. 2024. doi:10.1038/s41587-023-02078-y