Wu B, Chang H, Singh P, et al. Small molecule modulators of TOX protein re-invigorate T cell activity. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.03.03.641115
Chemical Biology and Therapeutics Science Program
Waterbury AL, Caroli J, Zhang O, et al. Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Nature communications. 2025;16(1):3156. doi:10.1038/s41467-025-57477-3
Sreekanth V, Sindi SH, Chaudhary SK, et al. Ultrasmall Chemogenetic Tags with Group-Transfer Ligands. Angewandte Chemie (International ed. in English). 2025:e202506997. doi:10.1002/anie.202506997
Yeo MJR, Zhang O, Xie X, et al. UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors. Nature. 2025. doi:10.1038/s41586-024-08532-4
Chan A, Kirtane AR, Qu QR, et al. Designing lipid nanoparticles using a transformer-based neural network. Nature nanotechnology. 2025. doi:10.1038/s41565-025-01975-4
Maurer K, Weir JA, Nagler A, et al. A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapy. Nature communications. 2025;16(1):7462. doi:10.1038/s41467-025-62709-7
Merz M. Orthogonal resistance mechanisms of classical- and induced-proximity inhibitors. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.05.10.652755
Lee K, Barone M, Waterbury AL, et al. Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1. Nature chemical biology. 2024. doi:10.1038/s41589-024-01671-9
Raguram A, An M, Chen PZ, Liu DR. Directed evolution of engineered virus-like particles with improved production and transduction efficiencies. Nature biotechnology. 2024. doi:10.1038/s41587-024-02467-x
Du SW, Newby GA, Salom D, et al. In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice. Proceedings of the National Academy of Sciences of the United States of America. 2024;121(48):e2416827121. doi:10.1073/pnas.2416827121