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Chemical Biology and Therapeutics Science Program
Waterbury AL, Iram I, Liau BB. Building the first base editors. Nature chemical biology. 2025;21(1):16-17. doi:10.1038/s41589-024-01790-3
Xie X, Zhang O, Yeo MJR, et al. Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations. Nature. 2025. doi:10.1038/s41586-024-08533-3
Yu R, Roseman S, Siegenfeld AP, et al. CTCF/RAD21 organize the ground state of chromatin-nuclear speckle association. Nature structural & molecular biology. 2025. doi:10.1038/s41594-024-01465-6
Waterbury AL, Caroli J, Zhang O, et al. Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Nature communications. 2025;16(1):3156. doi:10.1038/s41467-025-57477-3
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Lloyd HC, Li Y, Payne C, et al. A method for the detection and enrichment of endogenous cereblon substrates. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.03.24.645063
Yeo MJR, Zhang O, Xie X, et al. UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors. Nature. 2025. doi:10.1038/s41586-024-08532-4
Zhang J, Ali MY, Chong HB, et al. Oxidation of retromer complex controls mitochondrial translation. Nature. 2025. doi:10.1038/s41586-025-08756-y
An M, Davis JR, Levy JM, et al. In vivo base editing extends lifespan of a humanized mouse model of prion disease. Nature medicine. 2025. doi:10.1038/s41591-024-03466-w