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Eric Lander

Comprehensive genomic characterization defines human glioblastoma genes and core pathways.

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Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455(7216):1061-8. doi:10.1038/nature07385.

Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.

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Ku M, Koche RP, Rheinbay E, et al. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet. 2008;4(10):e1000242. doi:10.1371/journal.pgen.1000242.

Genome-scale DNA methylation maps of pluripotent and differentiated cells.

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Meissner A, Mikkelsen TS, Gu H, et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature. 2008;454(7205):766-70. doi:10.1038/nature07107.

Dissecting direct reprogramming through integrative genomic analysis.

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Mikkelsen TS, Hanna J, Zhang X, et al. Dissecting direct reprogramming through integrative genomic analysis. Nature. 2008;454(7200):49-55. doi:10.1038/nature07056.

cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism.

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Freeman RM, Wu M, Cordonnier-Pratt M-M, et al. cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism. Biol Bull. 2008;214(3):284-302. doi:10.2307/25470670.

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways.

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Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 2008;68(10):3645-54. doi:10.1158/0008-5472.CAN-07-2938.

ALLPATHS: de novo assembly of whole-genome shotgun microreads.

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Butler J, MacCallum I, Kleber M, et al. ALLPATHS: de novo assembly of whole-genome shotgun microreads. Genome Res. 2008;18(5):810-20. doi:10.1101/gr.7337908.

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.

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Neafsey DE, Schaffner SF, Volkman SK, et al. Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biol. 2008;9(12):R171. doi:10.1186/gb-2008-9-12-r171.

Distinct physiological states of Plasmodium falciparum in malaria-infected patients.

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Daily JP, Scanfeld D, Pochet N, et al. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature. 2007;450(7172):1091-5. doi:10.1038/nature06311.

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma.

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Beroukhim R, Getz G, Nghiemphu L, et al. Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A. 2007;104(50):20007-12. doi:10.1073/pnas.0710052104.