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Eric Lander

Rewriting regulatory DNA to dissect and reprogram gene expression.

1.

Martyn GE, Montgomery MT, Jones H, et al. Rewriting regulatory DNA to dissect and reprogram gene expression. Cell. 2025. doi:10.1016/j.cell.2025.03.034.

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes.

1.

Martin-Rufino JD, Caulier A, Lee S, et al. Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes. Science (New York, N.Y.). 2025;388(6742):52-59. doi:10.1126/science.ads7951.

Convergence of coronary artery disease genes onto endothelial cell programs.

1.

Schnitzler GR, Kang H, Fang S, et al. Convergence of coronary artery disease genes onto endothelial cell programs. Nature. 2024. doi:10.1038/s41586-024-07022-x.

A standing platform for cancer drug development using ctDNA-based evidence of recurrence.

1.

Medford AJ, Carmeli AB, Ritchie A, et al. A standing platform for cancer drug development using ctDNA-based evidence of recurrence. Nature reviews. Cancer. 2024. doi:10.1038/s41568-024-00742-2.

Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample.

1.

Sandoval-Velasco M, Dudchenko O, Rodríguez JA, et al. Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample. Cell. 2024;187(14):3541-3562.e51. doi:10.1016/j.cell.2024.06.002.

Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever.

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Kotliar D, Raju S, Tabrizi S, et al. Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever. Nature microbiology. 2024. doi:10.1038/s41564-023-01589-3.

Rewriting regulatory DNA to dissect and reprogram gene expression.

1.

Martyn GE, Montgomery MT, Jones H, et al. Rewriting regulatory DNA to dissect and reprogram gene expression. bioRxiv : the preprint server for biology. 2023. doi:10.1101/2023.12.20.572268.

Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies.

1.

Nowbandegani PS, Wohns AW, Ballard JL, et al. Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies. Nature genetics. 2023. doi:10.1038/s41588-023-01487-8.

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases.

1.

Weeks EM, Ulirsch JC, Cheng NY, et al. Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases. Nature genetics. 2023. doi:10.1038/s41588-023-01443-6.

Massively parallel base editing to map variant effects in human hematopoiesis.

1.

Martin-Rufino JD, Castano N, Pang M, et al. Massively parallel base editing to map variant effects in human hematopoiesis. Cell. 2023. doi:10.1016/j.cell.2023.03.035.