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Eric Lander

A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density.

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Sinnott-Armstrong N, Sousa IS, Laber S, et al. A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. Cell Metab. 2021;33(3):615-628.e13. doi:10.1016/j.cmet.2021.01.001.

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.

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Muus C, Luecken MD, Eraslan G, et al. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nat Med. 2021;27(3):546-559. doi:10.1038/s41591-020-01227-z.

Human Molecular Genetics and Genomics - Important Advances and Exciting Possibilities.

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Collins FS, Doudna JA, Lander ES, Rotimi CN. Human Molecular Genetics and Genomics - Important Advances and Exciting Possibilities. N Engl J Med. 2021;384(1):1-4. doi:10.1056/NEJMp2030694.

HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes.

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Marshall JL, Doughty BR, Subramanian V, et al. HyPR-seq: Single-cell quantification of chosen RNAs via hybridization and sequencing of DNA probes. Proc Natl Acad Sci U S A. 2020;117(52):33404-33413. doi:10.1073/pnas.2010738117.

Delivery Mode Affects Stability of Early Infant Gut Microbiota.

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Mitchell CM, Mazzoni C, Hogstrom L, et al. Delivery Mode Affects Stability of Early Infant Gut Microbiota. Cell Rep Med. 2020;1(9):100156. doi:10.1016/j.xcrm.2020.100156.

The SARS-CoV-2 RNA-protein interactome in infected human cells.

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Schmidt N, Lareau CA, Keshishian H, et al. The SARS-CoV-2 RNA-protein interactome in infected human cells. Nat Microbiol. 2020. doi:10.1038/s41564-020-00846-z.

A comparative genomics multitool for scientific discovery and conservation.

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Zoonomia Consortium. A comparative genomics multitool for scientific discovery and conservation. Nature. 2020;587(7833):240-245. doi:10.1038/s41586-020-2876-6.

Inherited causes of clonal haematopoiesis in 97,691 whole genomes.

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Bick AG, Weinstock JS, Nandakumar SK, et al. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020;586(7831):763-768. doi:10.1038/s41586-020-2819-2.

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions.

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Fahed AC, Wang M, Homburger JR, et al. Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions. Nat Commun. 2020;11(1):3635. doi:10.1038/s41467-020-17374-3.

Mapping and characterization of structural variation in 17,795 human genomes.

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Abel HJ, Larson DE, Regier AA, et al. Mapping and characterization of structural variation in 17,795 human genomes. Nature. 2020. doi:10.1038/s41586-020-2371-0.