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Publications

Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.

Rajavelu A, Lungu C, Emperle M, et al. Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2. Nucleic Acids Res. 2018;46(17):9044-9056. doi:10.1093/nar/gky715

Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification".

Stewart C, Leshchiner I, Hess J, Getz G. Comment on "DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification". Science. 2018;361(6409). doi:10.1126/science.aas9824

Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal Pathogen .

Sephton-Clark PCS, Muñoz JF, Ballou ER, Cuomo CA, Voelz K. Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal Pathogen . mSphere. 2018;3(5). doi:10.1128/mSphere.00403-18

Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis.

Velthorst E, Froudist-Walsh S, Stahl E, et al. Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis. Transl Psychiatry. 2018;8(1):204. doi:10.1038/s41398-018-0229-0

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.

Vojinovic D, Adams HH, Jian X, et al. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nat Commun. 2018;9(1):3945. doi:10.1038/s41467-018-06234-w

A scalable online tool for quantitative social network assessment reveals potentially modifiable social environmental risks.

Dhand A, White CC, Johnson C, Xia Z, De Jager PL. A scalable online tool for quantitative social network assessment reveals potentially modifiable social environmental risks. Nat Commun. 2018;9(1):3930. doi:10.1038/s41467-018-06408-6

Aligning Single-Cell Developmental and Reprogramming Trajectories Identifies Molecular Determinants of Myogenic Reprogramming Outcome.

Cacchiarelli D, Qiu X, Srivatsan S, et al. Aligning Single-Cell Developmental and Reprogramming Trajectories Identifies Molecular Determinants of Myogenic Reprogramming Outcome. Cell Syst. 2018;7(3):258-268.e3. doi:10.1016/j.cels.2018.07.006

De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis.

Wang S, Mandell JD, Kumar Y, et al. De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis. Cell Rep. 2018;24(13):3441-3454.e12. doi:10.1016/j.celrep.2018.08.082

Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.

Guerra RM, Bird GH, Harvey EP, et al. Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer. Cell Rep. 2018;24(13):3393-3403.e5. doi:10.1016/j.celrep.2018.08.089

Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection.

Shan Z, Clish CB, Hua S, et al. Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection. J Infect Dis. 2018;218(9):1474-1479. doi:10.1093/infdis/jiy356