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Publications

Genetics Sheds New Light on Congenital Hydrocephalus Biology.

Lal D, Palotie A. Genetics Sheds New Light on Congenital Hydrocephalus Biology. Neuron. 2018;99(2):246-247. doi:10.1016/j.neuron.2018.07.008

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain.

Felsky D, Patrick E, Schneider JA, et al. Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain. Mol Neurodegener. 2018;13(1):38. doi:10.1186/s13024-018-0272-6

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.

Graham DB, Jasso GJ, Mok A, et al. Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes. Cell Rep. 2018;24(4):838-850. doi:10.1016/j.celrep.2018.06.081

Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers.

Tsafou K, Katschnig AM, Radic-Sarikas B, et al. Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers. Oncotarget. 2018;9(57):31018-31031. doi:10.18632/oncotarget.25760

Positional specificity of different transcription factor classes within enhancers.

Grossman SR, Engreitz J, Ray JP, Nguyen TH, Hacohen N, Lander ES. Positional specificity of different transcription factor classes within enhancers. Proc Natl Acad Sci U S A. 2018;115(30):E7222-E7230. doi:10.1073/pnas.1804663115

A phosphoproteomic signature in endothelial cells predicts vascular toxicity of tyrosine kinase inhibitors used in CML.

Gopal S, Lu Q, Man JJ, et al. A phosphoproteomic signature in endothelial cells predicts vascular toxicity of tyrosine kinase inhibitors used in CML. Blood Adv. 2018;2(14):1680-1684. doi:10.1182/bloodadvances.2018020396

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

Lee JJ, Wedow R, Okbay A, et al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nat Genet. 2018;50(8):1112-1121. doi:10.1038/s41588-018-0147-3

Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections: a feint attack by parasites.

Liu D, Albergante L, Newman TJ, Horn D. Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections: a feint attack by parasites. Sci Rep. 2018;8(1):10922. doi:10.1038/s41598-018-29296-8

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

Prins BP, Mead TJ, Brody JA, et al. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biol. 2018;19(1):87. doi:10.1186/s13059-018-1457-6

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.

Conlon EG, Fagegaltier D, Agius P, et al. Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism. Elife. 2018;7. doi:10.7554/eLife.37754