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Publications

Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase.

Roh H, Shen S, Hu Y, et al. Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase. Nature methods. 2025. doi:10.1038/s41592-025-02811-2

Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects.

Karczewski K, Gupta R, Kanai M, et al. Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects. Nature genetics. 2025. doi:10.1038/s41588-025-02335-7

Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation.

Chen X, Hwang H, Li B, et al. Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(38):e2508269122. doi:10.1073/pnas.2508269122

Circulating tumor human papillomavirus DNA whole genome sequencing enables human papillomavirus-associated oropharynx cancer early detection.

Das D, Hirayama S, Aye L, et al. Circulating tumor human papillomavirus DNA whole genome sequencing enables human papillomavirus-associated oropharynx cancer early detection. Journal of the National Cancer Institute. 2025. doi:10.1093/jnci/djaf249

TissueMosaic: Self-supervised learning of tissue representations enables differential spatial transcriptomics across samples.

Kambhampati S, D’Alessio L, Grab F, et al. TissueMosaic: Self-supervised learning of tissue representations enables differential spatial transcriptomics across samples. Cell systems. 2025;16(9):101394. doi:10.1016/j.cels.2025.101394

Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis.

Merz M, Shoba V, Pergu R, et al. Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.06.13.659082

Orthogonal resistance mechanisms of classical- and induced-proximity inhibitors.

Merz M. Orthogonal resistance mechanisms of classical- and induced-proximity inhibitors. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.05.10.652755

TIGER: A tdTomato in vivo genome-editing reporter mouse for investigating precision-editor delivery approaches.

Du S. TIGER: A tdTomato in vivo genome-editing reporter mouse for investigating precision-editor delivery approaches. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(35):e2506257122. doi:10.1073/pnas.2506257122

Detection of heterogeneous resistance mechanisms to tyrosine kinase inhibitors from cell-free DNA.

Parsons HA, Messer C, Santos K, et al. Detection of heterogeneous resistance mechanisms to tyrosine kinase inhibitors from cell-free DNA. Cell genomics. 2025:100987. doi:10.1016/j.xgen.2025.100987

Supporting Participant Engagement in Cancer Genomics Research in Rare Cancers: A Qualitative Study of Patients, Caregivers, and Advocates.

Venkataraman V, Weber L, Fisher L, et al. Supporting Participant Engagement in Cancer Genomics Research in Rare Cancers: A Qualitative Study of Patients, Caregivers, and Advocates. Cancer control : journal of the Moffitt Cancer Center. 2025;32:10732748251364041. doi:10.1177/10732748251364041