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Publications

Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions.

Kotliar D, Curtis M, Agnew R, et al. Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functions. Nature methods. 2025. doi:10.1038/s41592-025-02793-1

Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis.

Haj AK, Paul DS, Jurgens SJ, et al. Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis. Nature communications. 2025;16(1):8176. doi:10.1038/s41467-025-62789-5

Genomic landscape and immunological profile of glioblastoma in East Asian patients.

Zhong S, Wu B, Dubois F, et al. Genomic landscape and immunological profile of glioblastoma in East Asian patients. Cell reports. Medicine. 2025;6(8):102217. doi:10.1016/j.xcrm.2025.102217

Adenine base editing rescues pathogenic phenotypes in tissue engineered vascular model of Hutchinson-Gilford progeria syndrome.

Abutaleb N, Gao X, Bedapudi A, et al. Adenine base editing rescues pathogenic phenotypes in tissue engineered vascular model of Hutchinson-Gilford progeria syndrome. APL bioengineering. 2025;9(1):016110. doi:10.1063/5.0244026

GFP-on mouse model for interrogation of in vivo gene editing.

Dib C, Queenan J, Swartzrock L, et al. GFP-on mouse model for interrogation of in vivo gene editing. Nature communications. 2025;16(1):7017. doi:10.1038/s41467-025-61449-y

Ultrasmall chemogenetic tags with group-transfer ligands.

Vedagopuram S, Sindi S, Chaudhary S, et al. Ultrasmall chemogenetic tags with group-transfer ligands. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.05.10.653252

Small molecule modulators of TOX protein re-invigorate T cell activity.

Wu B, Chang H, Singh P, et al. Small molecule modulators of TOX protein re-invigorate T cell activity. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.03.03.641115

Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function.

Liu Y, Gu X, Li Y, et al. Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function. Nature medicine. 2025. doi:10.1038/s41591-025-03891-5

Efficiently quantifying dependence in massive scientific datasets using InterDependence Scores.

Radhakrishnan A, Jain Y, Uhler C, Lander ES. Efficiently quantifying dependence in massive scientific datasets using InterDependence Scores. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(34):e2509860122. doi:10.1073/pnas.2509860122

Elucidating the role of Campylobacter concisus-derived indole metabolites in gut inflammation and immune modulation.

Park JD, Lee SR, Dhennezel C, et al. Elucidating the role of Campylobacter concisus-derived indole metabolites in gut inflammation and immune modulation. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(34):e2514071122. doi:10.1073/pnas.2514071122