Tissue specificity and chromosomal alterations shape divergent immune programs in HRD tumors. Gulhan DC, Barras D, Mina M, et al. Tissue specificity and chromosomal alterations shape divergent immune programs in HRD tumors. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.10.13.681986 PMCID PMC12633024 Read more
Epstein-Barr Virus Encoded lncRNAs Control the Viral Lytic Switch. Li Z, Liao Y, Ding W, et al. Epstein-Barr Virus Encoded lncRNAs Control the Viral Lytic Switch. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.10.29.685446 PMCID PMC12636365 Read more
Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in HSP90 Inhibitors. Ko FH, Lukens AK, de Souza ML, et al. Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in HSP90 Inhibitors. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.10.30.684657 PMCID PMC12636505 Read more
Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue. Middelbeek RJW, Yang J, Nigro P, et al. Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.10.11.681273 PMCID PMC12632298 Read more
ZMYND11 Restrains KMT2A to Enable a Neuronal Developmental Program. Greben AW, Wu XS, Robb JE, et al. ZMYND11 Restrains KMT2A to Enable a Neuronal Developmental Program. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.10.31.685692 PMCID PMC12636335 Read more
Improving performance of polygenic risk scores for hypertension across two ancestry groups. Irvin MR, Srinivasasainagendra V, Armstrong ND, et al. Improving performance of polygenic risk scores for hypertension across two ancestry groups. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.11.05.25339527 PMCID PMC12642749 Read more
PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores. Tian X, Fabiha T, Li WF, Dey KK, Kellis M, Tanigawa Y. PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.13.688144 PMCID PMC12642535 Read more
Agentic Lab: An Agentic-physical AI system for cell and organoid experimentation and manufacturing. Wang W, Swain S, Lee J, et al. Agentic Lab: An Agentic-physical AI system for cell and organoid experimentation and manufacturing. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.11.686354 PMCID PMC12642585 Read more
A Precisely Controlled Long-Acting Immunosuppression Platform Enables Prolonged Survival of Vascularized Composite Allografts. Lee S, Zor F, Kulahci Y, et al. A Precisely Controlled Long-Acting Immunosuppression Platform Enables Prolonged Survival of Vascularized Composite Allografts. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.07.687240 PMCID PMC12642550 Read more
CONCERT predicts niche-aware perturbation responses in spatial transcriptomics. Lin X, Kong Z, Ghosh S, Kellis M, Zitnik M. CONCERT predicts niche-aware perturbation responses in spatial transcriptomics. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.08.686890 PMCID PMC12642540 Read more