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Publications

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden.

Chalmers ZR, Connelly CF, Fabrizio D, et al. Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. Genome Med. 2017;9(1):34. doi:10.1186/s13073-017-0424-2

High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations.

Ndiaye YD, Diedhiou CK, Bei AK, et al. High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations. Malar J. 2017;16(1):153. doi:10.1186/s12936-017-1811-2

Designing Hydrogels for On-Demand Therapy.

Oliva N, Conde J, Wang K, Artzi N. Designing Hydrogels for On-Demand Therapy. Acc Chem Res. 2017;50(4):669-679. doi:10.1021/acs.accounts.6b00536

Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI).

Chen C, Xing D, Tan L, et al. Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI). Science. 2017;356(6334):189-194. doi:10.1126/science.aak9787

Discovery of Antimalarial Azetidine-2-carbonitriles That InhibitDihydroorotate Dehydrogenase.

Maetani M, Kato N, Jabor VAP, et al. Discovery of Antimalarial Azetidine-2-carbonitriles That InhibitDihydroorotate Dehydrogenase. ACS Med Chem Lett. 2017;8(4):438-442. doi:10.1021/acsmedchemlett.7b00030

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity.

Saleheen D, Natarajan P, Armean IM, et al. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 2017;544(7649):235-239. doi:10.1038/nature22034

Label-free volumetric optical imaging of intact murine brains.

Ren J, Choi H, Chung K, Bouma BE. Label-free volumetric optical imaging of intact murine brains. Sci Rep. 2017;7:46306. doi:10.1038/srep46306

Direct evidence for a polygenic etiology in familial multiple myeloma.

Halvarsson BM, Wihlborg AK, Ali M, et al. Direct evidence for a polygenic etiology in familial multiple myeloma. Blood Adv. 2017;1(10):619-623. doi:10.1182/bloodadvances.2016003111

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.

Platt RJ, Zhou Y, Slaymaker IM, et al. Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits. Cell Rep. 2017;19(2):335-350. doi:10.1016/j.celrep.2017.03.052

Toil enables reproducible, open source, big biomedical data analyses.

Vivian J, Rao AA, Nothaft FA, et al. Toil enables reproducible, open source, big biomedical data analyses. Nat Biotechnol. 2017;35(4):314-316. doi:10.1038/nbt.3772