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Publications

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Warren CR, O’Sullivan JF, Friesen M, et al. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017;20(4):547-557.e7. doi:10.1016/j.stem.2017.01.010

Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.

Pashos EE, Park Y, Wang X, et al. Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Cell Stem Cell. 2017;20(4):558-570.e10. doi:10.1016/j.stem.2017.03.017

Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations.

Martin AR, Gignoux CR, Walters RK, et al. Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations. Am J Hum Genet. 2017;100(4):635-649. doi:10.1016/j.ajhg.2017.03.004

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.

Herault A, Binnewies M, Leong S, et al. Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis. Nature. 2017;544(7648):53-58. doi:10.1038/nature21693

Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues.

Liu X, Finucane HK, Gusev A, et al. Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues. Am J Hum Genet. 2017;100(4):605-616. doi:10.1016/j.ajhg.2017.03.002

Large-Scale trans-eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation.

Brynedal B, Choi J, Raj T, et al. Large-Scale trans-eQTLs Affect Hundreds of Transcripts and Mediate Patterns of Transcriptional Co-regulation. Am J Hum Genet. 2017;100(4):581-591. doi:10.1016/j.ajhg.2017.02.004

Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia.

Wallace ML, Saunders A, Huang KW, et al. Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia. Neuron. 2017;94(1):138-152.e5. doi:10.1016/j.neuron.2017.03.017

Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.

Gasset-Rosa F, Chillon-Marinas C, Goginashvili A, et al. Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport. Neuron. 2017;94(1):48-57.e4. doi:10.1016/j.neuron.2017.03.027

Long-term use of antibiotics and risk of colorectal adenoma.

Cao Y, Wu K, Mehta R, et al. Long-term use of antibiotics and risk of colorectal adenoma. Gut. 2017. doi:10.1136/gutjnl-2016-313413

The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.

Mishima Y, Paiva B, Shi J, et al. The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma. Cell Rep. 2017;19(1):218-224. doi:10.1016/j.celrep.2017.03.025