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Publications

Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor.

Klarin D, Emdin CA, Natarajan P, Conrad MF, INVENT Consortium, Kathiresan S. Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. Circ Cardiovasc Genet. 2017;10(2). doi:10.1161/CIRCGENETICS.116.001643

It Takes a Village to Unmask HSTL.

Yoshida N, Weinstock DM. It Takes a Village to Unmask HSTL. Cancer Discov. 2017;7(4):352-353. doi:10.1158/2159-8290.CD-17-0160

The Path to New Therapies for Schizophrenia and Bipolar Illness.

Scolnick EM. The Path to New Therapies for Schizophrenia and Bipolar Illness. FASEB J. 2017;31(4):1254-1259. doi:10.1096/fj.201700028

Stem cell-derived neurons in the development of targeted treatment for schizophrenia and bipolar disorder.

Watmuff B, Liu B, Karmacharya R. Stem cell-derived neurons in the development of targeted treatment for schizophrenia and bipolar disorder. Pharmacogenomics. 2017;18(5):471-479. doi:10.2217/pgs-2016-0187

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.

Joung J, Konermann S, Gootenberg JS, et al. Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening. Nat Protoc. 2017;12(4):828-863. doi:10.1038/nprot.2017.016

Microbial strain-level population structure and genetic diversity from metagenomes.

Truong DT, Tett A, Pasolli E, Huttenhower C, Segata N. Microbial strain-level population structure and genetic diversity from metagenomes. Genome Res. 2017;27(4):626-638. doi:10.1101/gr.216242.116

Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations.

Ajore R, Raiser D, McConkey M, et al. Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations. EMBO Mol Med. 2017;9(4):498-507. doi:10.15252/emmm.201606660

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types.

Chun S, Casparino A, Patsopoulos NA, et al. Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types. Nat Genet. 2017;49(4):600-605. doi:10.1038/ng.3795

Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis.

Hoogman M, Bralten J, Hibar DP, et al. Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis. Lancet Psychiatry. 2017;4(4):310-319. doi:10.1016/S2215-0366(17)30049-4

The Weighting is the Hardest Part: On the Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples.

Minică CC, Genovese G, Hultman CM, et al. The Weighting is the Hardest Part: On the Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples. Twin Res Hum Genet. 2017;20(2):108-118. doi:10.1017/thg.2017.7