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Publications

A substrate-driven allosteric switch that enhances PDI catalytic activity.

Bekendam RH, Bendapudi PK, Lin L, et al. A substrate-driven allosteric switch that enhances PDI catalytic activity. Nat Commun. 2016;7:12579. doi:10.1038/ncomms12579

A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking.

Huan T, Joehanes R, Schurmann C, et al. A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Hum Mol Genet. 2016. doi:10.1093/hmg/ddw288

Seipin is required for converting nascent to mature lipid droplets.

Wang H, Becuwe M, Housden BE, et al. Seipin is required for converting nascent to mature lipid droplets. Elife. 2016;5. doi:10.7554/eLife.16582

Leveraging human genetics to guide drug target discovery.

Stitziel NO, Kathiresan S. Leveraging human genetics to guide drug target discovery. Trends Cardiovasc Med. 2016. doi:10.1016/j.tcm.2016.08.008

Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons.

Habib N, Li Y, Heidenreich M, et al. Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons. Science. 2016;353(6302):925-8. doi:10.1126/science.aad7038

Opportunities and challenges in modeling human brain disorders in transgenic primates.

Jennings CG, Landman R, Zhou Y, et al. Opportunities and challenges in modeling human brain disorders in transgenic primates. Nat Neurosci. 2016;19(9):1123-30. doi:10.1038/nn.4362

The hippocampus grows up.

Rudenko A, Tsai LH. The hippocampus grows up. Nat Neurosci. 2016;19(9):1190-1. doi:10.1038/nn.4368

Discovery of a proteinaceous cellular receptor for a norovirus.

Orchard RC, Wilen CB, Doench JG, et al. Discovery of a proteinaceous cellular receptor for a norovirus. Science. 2016;353(6302):933-6. doi:10.1126/science.aaf1220

Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury.

Polimanti R, Chen CY, Ursano RJ, et al. Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury. J Neurotrauma. 2016. doi:10.1089/neu.2016.4550

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.

Zhang X, Chen MH, Wu X, et al. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016;166(5):1147-1162.e15. doi:10.1016/j.cell.2016.07.025