ӳ��ý

Publications

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.

Joshi PK, Fischer K, Schraut KE, Campbell H, Esko T, Wilson JF. Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan. Nat Commun. 2016;7:11174. doi:10.1038/ncomms11174

Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.

Stringer S, Minică CC, Verweij KJH, et al. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. Transl Psychiatry. 2016;6:e769. doi:10.1038/tp.2016.36

Leveraging signaling research to understand and treat disease.

Yaffe MB, Gough NR. Leveraging signaling research to understand and treat disease. Sci Signal. 2016;9(421):eg4. doi:10.1126/scisignal.aaf6275

G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.

Kedersha N, Panas MD, Achorn CA, et al. G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2016;212(7):845-60. doi:10.1083/jcb.201508028

Personal Genome Sequencing in Ostensibly Healthy Individuals and the PeopleSeq Consortium.

Linderman MD, Nielsen DE, Green RC. Personal Genome Sequencing in Ostensibly Healthy Individuals and the PeopleSeq Consortium. J Pers Med. 2016;6(2). doi:10.3390/jpm6020014

CANCER. The oncogene makes its escape.

Wala J, Beroukhim R. CANCER. The oncogene makes its escape. Science. 2016;351(6280):1398-9. doi:10.1126/science.aaf5542

Survey of variation in human transcription factors reveals prevalent DNA binding changes.

Barrera LA, Vedenko A, Kurland JV, et al. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science. 2016;351(6280):1450-4. doi:10.1126/science.aad2257

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.

McGranahan N, Furness AJS, Rosenthal R, et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science. 2016;351(6280):1463-9. doi:10.1126/science.aaf1490

Function and evolution of local repeats in the Firre locus.

Hacisuleyman E, Shukla CJ, Weiner CL, Rinn JL. Function and evolution of local repeats in the Firre locus. Nat Commun. 2016;7:11021. doi:10.1038/ncomms11021

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection.

Tran MT, Zsengeller ZK, Berg AH, et al. PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature. 2016;531(7595):528-32. doi:10.1038/nature17184