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Publications

Sestrin2 is a leucine sensor for the mTORC1 pathway.

Wolfson RL, Chantranupong L, Saxton RA, et al. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science. 2016;351(6268):43-8. doi:10.1126/science.aab2674

Across-cohort QC analyses of GWAS summary statistics from complex traits.

Chen GB, Lee SH, Robinson MR, et al. Across-cohort QC analyses of GWAS summary statistics from complex traits. Eur J Hum Genet. 2016;25(1):137-146. doi:10.1038/ejhg.2016.106

BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology.

Shankar GM, Lelic N, Gill CM, et al. BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology. Acta Neuropathol. 2016;131(1):147-50. doi:10.1007/s00401-015-1492-2

Reply to Melillo: Woranso-Mille is consistent with an australopithecine shoulder intermediate between African apes and Homo.

Young NM, Capellini TD, Roach NT, Alemseged Z. Reply to Melillo: Woranso-Mille is consistent with an australopithecine shoulder intermediate between African apes and Homo. Proc Natl Acad Sci U S A. 2015;112(52):E7160. doi:10.1073/pnas.1521824112

HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.

Ombrello MJ, Remmers EF, Tachmazidou I, et al. HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis. Proc Natl Acad Sci U S A. 2015;112(52):15970-5. doi:10.1073/pnas.1520779112

Genome-wide patterns of selection in 230 ancient Eurasians.

Mathieson I, Lazaridis I, Rohland N, et al. Genome-wide patterns of selection in 230 ancient Eurasians. Nature. 2015;528(7583):499-503. doi:10.1038/nature16152

The Molecular Signatures Database (MSigDB) hallmark gene set collection.

Liberzon A, Birger C, Thorvaldsdóttir H, Ghandi M, Mesirov JP, Tamayo P. The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst. 2015;1(6):417-425. doi:10.1016/j.cels.2015.12.004

High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction.

McClay JL, Shabalin AA, Dozmorov MG, et al. High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction. Genome Biol. 2015;16:291. doi:10.1186/s13059-015-0842-7

Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.

Burak F, Inouye KE, White A, et al. Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Sci Transl Med. 2015;7(319):319ra205. doi:10.1126/scitranslmed.aac6336

RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability.

Chen E, Ahn JS, Sykes DB, et al. RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability. Cell Rep. 2015;13(11):2345-52. doi:10.1016/j.celrep.2015.11.037