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Publications

Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy.

Dejanovic B, Djémié T, Grünewald N, et al. Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy. EMBO Mol Med. 2015;7(12):1580-94. doi:10.15252/emmm.201505323

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.

March S, Ramanan V, Trehan K, et al. Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens. Nat Protoc. 2015;10(12):2027-53. doi:10.1038/nprot.2015.128

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

Gaulton KJ, Ferreira T, Lee Y, et al. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet. 2015;47(12):1415-25. doi:10.1038/ng.3437

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.

Kim KH, Kim W, Howard TP, et al. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat Med. 2015;21(12):1491-6. doi:10.1038/nm.3968

Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomization Meta-Analysis in the CARTA Consortium.

Linneberg A, Jacobsen RK, Skaaby T, et al. Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomization Meta-Analysis in the CARTA Consortium. Circ Cardiovasc Genet. 2015;8(6):832-41. doi:10.1161/CIRCGENETICS.115.001225

A bivariate Genome Wide Association Study (GWAS) of depressive symptoms and lipid levels has identified pleiotropic gene loci.

Amare A, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) depression working G, Global Lipids Genetics C, et al. A bivariate Genome Wide Association Study (GWAS) of depressive symptoms and lipid levels has identified pleiotropic gene loci. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2015;47(Pt A):113-4. doi:10.1016/j.ijdevneu.2015.04.305

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis.

Loh PR, Bhatia G, Gusev A, et al. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nat Genet. 2015;47(12):1385-92. doi:10.1038/ng.3431

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women.

Griesbeck M, Ziegler S, Laffont S, et al. Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women. J Immunol. 2015;195(11):5327-36. doi:10.4049/jimmunol.1501684

Lenalidomide: deciphering mechanisms of action in myeloma, myelodysplastic syndrome and beyond.

Guirguis AA, Ebert BL. Lenalidomide: deciphering mechanisms of action in myeloma, myelodysplastic syndrome and beyond. Curr Opin Cell Biol. 2015;37:61-7. doi:10.1016/j.ceb.2015.10.004

Hitting the Target in BRAF-Mutant Colorectal Cancer.

Nagaraja AK, Bass AJ. Hitting the Target in BRAF-Mutant Colorectal Cancer. J Clin Oncol. 2015;33(34):3990-2. doi:10.1200/JCO.2015.63.7793