Acetoacetate suppresses colon cancer via an MR1-MAIT axis. Clay SL, Tekle GE, Rashan EH, et al. Acetoacetate suppresses colon cancer via an MR1-MAIT axis. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.10.29.685375 PMCID PMC12636443 Read more
Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in HSP90 Inhibitors. Ko FH, Lukens AK, de Souza ML, et al. Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in HSP90 Inhibitors. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.10.30.684657 PMCID PMC12636505 Read more
Improving performance of polygenic risk scores for hypertension across two ancestry groups. Irvin MR, Srinivasasainagendra V, Armstrong ND, et al. Improving performance of polygenic risk scores for hypertension across two ancestry groups. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.11.05.25339527 PMCID PMC12642749 Read more
PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores. Tian X, Fabiha T, Li WF, Dey KK, Kellis M, Tanigawa Y. PRISM: ancestry-aware integration of tissue-specific genomic annotations enhances the transferability of polygenic scores. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.13.688144 PMCID PMC12642535 Read more
Agentic Lab: An Agentic-physical AI system for cell and organoid experimentation and manufacturing. Wang W, Swain S, Lee J, et al. Agentic Lab: An Agentic-physical AI system for cell and organoid experimentation and manufacturing. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.11.686354 PMCID PMC12642585 Read more
A Precisely Controlled Long-Acting Immunosuppression Platform Enables Prolonged Survival of Vascularized Composite Allografts. Lee S, Zor F, Kulahci Y, et al. A Precisely Controlled Long-Acting Immunosuppression Platform Enables Prolonged Survival of Vascularized Composite Allografts. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.07.687240 PMCID PMC12642550 Read more
CONCERT predicts niche-aware perturbation responses in spatial transcriptomics. Lin X, Kong Z, Ghosh S, Kellis M, Zitnik M. CONCERT predicts niche-aware perturbation responses in spatial transcriptomics. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.08.686890 PMCID PMC12642540 Read more
Challenges in Predicting Chromatin Accessibility Differences between Species. Stephen A, Raje A, Sestili HH, et al. Challenges in Predicting Chromatin Accessibility Differences between Species. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.09.687449 PMCID PMC12642317 Read more
Reversing transgene silencing via targeted chromatin editing. Palacios S, Salibi E, Lu E, et al. Reversing transgene silencing via targeted chromatin editing. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.10.28.685244 PMCID PMC12636370 Read more
igv-reports: Embedding interactive genomic visualizations in HTML reports to aid variant review. Robinson JT, Thorvaldsdottir H, Mesirov JP. igv-reports: Embedding interactive genomic visualizations in HTML reports to aid variant review. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.10.29.685397 PMCID PMC12636309 Read more