Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism. Yuan G, Suresh V, Wigdor E, et al. Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.05.686845 PMCID PMC12637482 Read more
Generative Design of Cell Type-Specific RNA Splicing Elements for Programmable Gene Regulation. Chen XD, Jim M, Vallurupalli M, et al. Generative Design of Cell Type-Specific RNA Splicing Elements for Programmable Gene Regulation. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.05.686847 PMCID PMC12637576 Read more
Proteogenomic profiling of soft tissue leiomyosarcoma reveals distinct molecular subtypes with divergent outcomes and therapeutic vulnerabilities. Tanaka A, Ogawa M, Otani Y, et al. Proteogenomic profiling of soft tissue leiomyosarcoma reveals distinct molecular subtypes with divergent outcomes and therapeutic vulnerabilities. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.19.689365 PMCID PMC12667925 Read more
Large-scale discovery of neural enhancers for cis-regulation therapies. McDiarmid TA, Page NF, Chardon FM, et al. Large-scale discovery of neural enhancers for cis-regulation therapies. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.04.686611 PMCID PMC12637570 Read more
A chromatin fiber model explains cell-free DNA fragmentation signatures of active regulatory elements. Yang A, Lee GG, Chhetri S, et al. A chromatin fiber model explains cell-free DNA fragmentation signatures of active regulatory elements. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.06.686988 PMCID PMC12637484 Read more
Adaptive resampling for improved machine learning in imbalanced single-cell datasets. Navidi Z, Thoutam A, Hughes M, et al. Adaptive resampling for improved machine learning in imbalanced single-cell datasets. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.04.686583 PMCID PMC12637690 Read more
A spatial transcriptomic atlas of autism-associated genes identifies convergence in the developing human thalamus. Aivazidis A, Memi F, Rademaker K, et al. A spatial transcriptomic atlas of autism-associated genes identifies convergence in the developing human thalamus. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.05.685843 PMCID PMC12637553 Read more
Deep-learning-derived glaucoma-related endophenotypes enable novel genome-wide genetic and functional discovery. Chen L, Zhao Y, Hashemabad SK, et al. Deep-learning-derived glaucoma-related endophenotypes enable novel genome-wide genetic and functional discovery. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.11.04.25339517 PMCID PMC12637757 Read more
An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy. Giadone RM, Holton KM, Hu X, et al. An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.11.04.686319 PMCID PMC12637412 Read more
Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy. Knight AD, Robitschek EJ, Lin JR, et al. Melanoma to rhabdomyosarcoma plasticity in the setting of immunotherapy. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.10.31.25338685 PMCID PMC12637767 Read more