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Publications

Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA).

Qiu T, Zhuang Z, Byun WS, et al. Development of FBXO22 Degraders and the Recruitment Ligand 2-Pyridinecarboxyaldehyde (2-PCA). Journal of the American Chemical Society. 2025. doi:10.1021/jacs.5c14141

Association of metabolomics measurements with blood cell phenotypes.

Chen BD, Tapia A, Boerwinkle E, et al. Association of metabolomics measurements with blood cell phenotypes. Blood cells, molecules & diseases. 2025;117:102966. doi:10.1016/j.bcmd.2025.102966

Opportunistic screening of type 2 diabetes with deep metric learning using electronic health records.

Jin Q, Zhang H, Szczerbinski L, et al. Opportunistic screening of type 2 diabetes with deep metric learning using electronic health records. Scientific reports. 2025;15(1):41892. doi:10.1038/s41598-025-25759-x

Proteome-wide model for human disease genetics.

Orenbuch R, Shearer CA, Kollasch AW, et al. Proteome-wide model for human disease genetics. Nature genetics. 2025. doi:10.1038/s41588-025-02400-1

Scalable spatial single-cell transcriptomics and translatomics in 3D thick tissue blocks.

Sui X, Lo JA, Luo S, et al. Scalable spatial single-cell transcriptomics and translatomics in 3D thick tissue blocks. Nature methods. 2025. doi:10.1038/s41592-025-02867-0

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis.

Minetti A, Omrani O, Brenner C, et al. Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis. Nature cell biology. 2025. doi:10.1038/s41556-025-01804-9

Solving the where problem and quantifying geometric variation in neuroanatomy using generative diffeomorphic mapping.

Tward DJ, Gray BDP, Li X, et al. Solving the where problem and quantifying geometric variation in neuroanatomy using generative diffeomorphic mapping. Nature communications. 2025;16(1):10398. doi:10.1038/s41467-025-65317-7

Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge.

Zhang Z, Bao X, Jiang L, et al. Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge. Nucleic acids research. 2025;53(21). doi:10.1093/nar/gkaf1269

A Lack of Information About Family Health History Motivates Adopted Individuals to Pursue Elective Genomic Testing.

Hickingbotham MR, Bell M, Zoltick ES, et al. A Lack of Information About Family Health History Motivates Adopted Individuals to Pursue Elective Genomic Testing. American journal of medical genetics. Part A. 2025:e70005. doi:10.1002/ajmga.70005

Leveraging a Genetic Proxy to Investigate the Effects of Lifelong Cardiac Sodium Channel Blockade.

Wanner JS, Krafft M, Niiranen T, et al. Leveraging a Genetic Proxy to Investigate the Effects of Lifelong Cardiac Sodium Channel Blockade. Circulation. 2025. doi:10.1161/CIRCULATIONAHA.125.075057