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Publications

mA modification of mutant huntingtin RNA promotes the biogenesis of pathogenic huntingtin transcripts.

Pupak A, Rodríguez-Navarro I, Sathasivam K, et al. mA modification of mutant huntingtin RNA promotes the biogenesis of pathogenic huntingtin transcripts. EMBO reports. 2024. doi:10.1038/s44319-024-00283-7

Model-directed generation of artificial CRISPR-Cas13a guide RNA sequences improves nucleic acid detection.

Mantena S, Pillai PP, Petros BA, et al. Model-directed generation of artificial CRISPR-Cas13a guide RNA sequences improves nucleic acid detection. Nature biotechnology. 2024. doi:10.1038/s41587-024-02422-w

A community effort to optimize sequence-based deep learning models of gene regulation.

Rafi AM, Nogina D, Penzar D, et al. A community effort to optimize sequence-based deep learning models of gene regulation. Nature biotechnology. 2024. doi:10.1038/s41587-024-02414-w

Single-shot 20-fold expansion microscopy.

Wang S, Shin TW, Yoder HB, et al. Single-shot 20-fold expansion microscopy. Nature methods. 2024. doi:10.1038/s41592-024-02454-9

Breaking the barriers: Overcoming cancer resistance by targeting the NLRP3 inflammasome.

Far NP, Varnousafaderani MH, Faghihkhorasani F, et al. Breaking the barriers: Overcoming cancer resistance by targeting the NLRP3 inflammasome. British journal of pharmacology. 2024. doi:10.1111/bph.17352

Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma.

Gallitto M, Zhang X, Santos GDL, et al. Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma. Neuro-oncology. 2024. doi:10.1093/neuonc/noae215

Comprehensive profile of the companion animal gut microbiome integrating reference-based and reference-free methods.

Branck T, Hu Z, Nickols WA, et al. Comprehensive profile of the companion animal gut microbiome integrating reference-based and reference-free methods. The ISME journal. 2024. doi:10.1093/ismejo/wrae201

Same Day Access to Folded Synthetic Proteins.

Callahan AJ, Rondon A, Reja RM, et al. Same Day Access to Folded Synthetic Proteins. Journal of the American Chemical Society. 2024. doi:10.1021/jacs.4c05121

scooby: Modeling multi-modal genomic profiles from DNA sequence at single-cell resolution.

Hingerl JC, Martens LD, Karollus A, et al. scooby: Modeling multi-modal genomic profiles from DNA sequence at single-cell resolution. bioRxiv : the preprint server for biology. 2024. doi:10.1101/2024.09.19.613754

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.

García-Marín LM, Campos AI, Diaz-Torres S, et al. Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. medRxiv : the preprint server for health sciences. 2024. doi:10.1101/2024.08.13.24311922