Publications

Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy.

Leylek O, Honeywell ME, Lee MJ, Hemann MT, Ozcan G. Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2024. doi:10.1007/s10120-024-01537-y

Subunit-specific analysis of cohesin-mutant myeloid malignancies reveals distinct ontogeny and outcomes.

Jann JC, Hergott CB, Winkler M, et al. Subunit-specific analysis of cohesin-mutant myeloid malignancies reveals distinct ontogeny and outcomes. Leukemia. 2024. doi:10.1038/s41375-024-02347-y

Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders.

Jurgens JA, Barry BJ, Chan WM, et al. Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders. Genetics in medicine : official journal of the American College of Medical Genetics. 2024:101216. doi:10.1016/j.gim.2024.101216

Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites.

Maurizio M, Masid M, Woods K, et al. Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites. Nature communications. 2024;15(1):6145. doi:10.1038/s41467-024-50405-x

Phenazine-1 carboxylic acid of induces the expression of Tet38 MDR efflux pump and mediates resistance to phenazines and antibiotics.

Truong-Bolduc QC, Wang Y, Lawton BG, et al. Phenazine-1 carboxylic acid of induces the expression of Tet38 MDR efflux pump and mediates resistance to phenazines and antibiotics. Antimicrobial agents and chemotherapy. 2024:e0063624. doi:10.1128/aac.00636-24

Genetic testing in early-onset atrial fibrillation.

Kany S, Jurgens SJ, Rämö JT, et al. Genetic testing in early-onset atrial fibrillation. European heart journal. 2024. doi:10.1093/eurheartj/ehae298

Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation.

Neale I, Reddy C, Tan ZY, et al. Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation. Science advances. 2024;10(29):eadn2339. doi:10.1126/sciadv.adn2339

Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study.

Rajasundaram S, Segrè A V, Gill D, et al. Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study. Investigative ophthalmology & visual science. 2024;65(8):35. doi:10.1167/iovs.65.8.35

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer.

Duplaquet L, So K, Ying AW, et al. Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer. Cancer cell. 2024. doi:10.1016/j.ccell.2024.06.012

Unsupervised representation learning of chromatin images identifies changes in cell state and tissue organization in DCIS.

Zhang X, Venkatachalapathy S, Paysan D, et al. Unsupervised representation learning of chromatin images identifies changes in cell state and tissue organization in DCIS. Nature communications. 2024;15(1):6112. doi:10.1038/s41467-024-50285-1

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Publications

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