ӳ��ý

Publications

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation.

Słabicki M. Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Molecular cell. 2025;85(16):3184-3201.e14. doi:10.1016/j.molcel.2025.07.019

A generative deep learning approach to de novo antibiotic design.

Krishnan A. A generative deep learning approach to de novo antibiotic design. Cell. 2025. doi:10.1016/j.cell.2025.07.033

Integrative genomic identification of therapeutic targets for pancreatic cancer.

Guo JA, Gong D, Evans K, et al. Integrative genomic identification of therapeutic targets for pancreatic cancer. Cell reports. 2025;44(9):116191. doi:10.1016/j.celrep.2025.116191

The evolution of hominin bipedalism in two steps.

Senevirathne G, Fernandopulle SC, Richard D, et al. The evolution of hominin bipedalism in two steps. Nature. 2025. doi:10.1038/s41586-025-09399-9

Genomic landscape and immunological profile of glioblastoma in East Asian patients.

Zhong S, Wu B, Dubois F, et al. Genomic landscape and immunological profile of glioblastoma in East Asian patients. Cell reports. Medicine. 2025;6(8):102217. doi:10.1016/j.xcrm.2025.102217

Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function.

Liu Y, Gu X, Li Y, et al. Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function. Nature medicine. 2025. doi:10.1038/s41591-025-03891-5

Efficiently quantifying dependence in massive scientific datasets using InterDependence Scores.

Radhakrishnan A, Jain Y, Uhler C, Lander ES. Efficiently quantifying dependence in massive scientific datasets using InterDependence Scores. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(34):e2509860122. doi:10.1073/pnas.2509860122

Elucidating the role of Campylobacter concisus-derived indole metabolites in gut inflammation and immune modulation.

Park JD, Lee SR, Dhennezel C, et al. Elucidating the role of Campylobacter concisus-derived indole metabolites in gut inflammation and immune modulation. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(34):e2514071122. doi:10.1073/pnas.2514071122

Integrative proteogenomics and forward genetics reveals a novel mitotic vulnerability in triple-negative breast cancer.

Neill NJ, Satpathy S, Krug K, et al. Integrative proteogenomics and forward genetics reveals a novel mitotic vulnerability in triple-negative breast cancer. Cancer discovery. 2025. doi:10.1158/2159-8290.CD-23-1173

A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapy.

Maurer K, Weir JA, Nagler A, et al. A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapy. Nature communications. 2025;16(1):7462. doi:10.1038/s41467-025-62709-7