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Publications

The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity.

Zhou Y, Ahsan FM, Emans SW, Soukas AA. The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity. Molecular cell. 2025. doi:10.1016/j.molcel.2025.08.035

Bead-based approaches for increased sensitivity and multiplexing of CRISPR diagnostics.

Siddiqui SM, Welch NL, Nguyen TG, et al. Bead-based approaches for increased sensitivity and multiplexing of CRISPR diagnostics. Nature biomedical engineering. 2025. doi:10.1038/s41551-025-01498-2

Systematic benchmarking of computational methods to identify spatially variable genes.

Li Z, Patel ZM, Song D, et al. Systematic benchmarking of computational methods to identify spatially variable genes. Genome biology. 2025;26(1):285. doi:10.1186/s13059-025-03731-2

Transcriptome-wide outlier approach identifies individuals with minor spliceopathies.

Arriaga TM, Mendez R, Ungar RA, et al. Transcriptome-wide outlier approach identifies individuals with minor spliceopathies. American journal of human genetics. 2025. doi:10.1016/j.ajhg.2025.08.018

In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma.

Knudsen NH, Escobar G, Korell F, et al. In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma. Nature. 2025. doi:10.1038/s41586-025-09489-8

Rapid epigenomic classification of acute leukemia.

Steinicke TL, Benfatto S, Capilla-Guerra MR, et al. Rapid epigenomic classification of acute leukemia. Nature genetics. 2025. doi:10.1038/s41588-025-02321-z

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation.

Xu J, Kong L, Creasey EA, et al. Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation. The Journal of experimental medicine. 2025;222(11). doi:10.1084/jem.20250185

Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation: Results in 18,000 Clinical Trial Participants.

Jurgens SJ, Melloni GEM, Kany S, et al. Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation: Results in 18,000 Clinical Trial Participants. Journal of the American College of Cardiology. 2025;86(10):738-753. doi:10.1016/j.jacc.2025.06.052

Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase.

Roh H, Shen S, Hu Y, et al. Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase. Nature methods. 2025. doi:10.1038/s41592-025-02811-2

Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects.

Karczewski K, Gupta R, Kanai M, et al. Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects. Nature genetics. 2025. doi:10.1038/s41588-025-02335-7